Folic Acid NHS Ester

• CAT Number: R036251
• CAS Number: 153445-05-7
• Molecular Formula: C23H22N8O8
• Molecular Weight: 538.48
• Purity: ≥95%
• Synonyms: (S)-2-(4-(((2-Amino-4-oxo-4,8-dihydropteridin-6-yl)methyl)amino)benzamido)-5-((2,5-dioxopyrrolidin-1-yl)oxy)-5-oxopentanoic Acid
• Storage: -20°C
• IUPAC Name: (2S)-2-[[4-[(2-amino-4-oxo-3H-pteridin-6-yl)methylamino]benzoyl]amino]-5-(2,5-dioxopyrrolidin-1-yl)oxy-5-oxopentanoic acid
• InChI: InChI=1S/C23H22N8O8/c24-23-29-19-18(21(36)30-23)27-13(10-26-19)9-25-12-3-1-11(2-4-12)20(35)28-14(22(37)38)5-8-17(34)39-31-15(32)6-7-16(31)33/h1-4,10,14,25H,5-9H2,(H,28,35)(H,37,38)(H3,24,26,29,30,36)/t14-/m0/s1
• InChIKey: JQGNXMQTFMHNHC-AWEZNQCLSA-N
• SMILES: C1CC(=O)N(C1=O)OC(=O)CCC(C(=O)O)NC(=O)C2=CC=C(C=C2)NCC3=CN=C4C(=N3)C(=O)NC(=N4)N

Folic Acid NHS Ester（Cat No.:R036251）is a chemically modified form of folic acid, where the N-hydroxysuccinimide (NHS) ester group is introduced to facilitate bioconjugation. This esterification enables the efficient coupling of folic acid to various biomolecules, such as proteins, peptides, and nanoparticles, enhancing their targeting capabilities. In biomedical research, Folic Acid NHS Ester is widely used to develop targeted drug delivery systems, particularly for cancer therapy, as it exploits the high affinity of folate receptors on cancer cells. This targeted approach improves therapeutic efficacy and reduces off-target effects, advancing precision medicine.