For research use only. Not for therapeutic Use.
Folate-PEG3-azide(CAT: I016241) is a heterobifunctional linker combining a folic acid moiety with an azide group, connected via a triethylene glycol (PEG3) spacer. The folate unit targets folate receptors, which are overexpressed in many cancer cells, enabling selective uptake and enhanced tumor targeting. The azide group allows bioorthogonal conjugation through copper-catalyzed or strain-promoted click chemistry, facilitating stable attachment to alkyne-functionalized probes, drugs, or imaging agents. The PEG3 spacer improves solubility, reduces steric hindrance, and enhances biocompatibility. Folate-PEG3-azide is particularly valuable in cancer research for developing targeted inhibitors, drug–conjugates, and imaging tools to study receptor-mediated drug delivery and tumor biology.
| CAS Number | 1313026-32-2 |
| Synonyms | (2S)-2-[[4-[(2-amino-4-oxo-3H-pteridin-6-yl)methylamino]benzoyl]amino]-5-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethylamino]-5-oxopentanoic acid |
| Molecular Formula | C27H35N11O8 |
| Purity | ≥95% |
| IUPAC Name | (2S)-2-[[4-[(2-amino-4-oxo-3H-pteridin-6-yl)methylamino]benzoyl]amino]-5-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethylamino]-5-oxopentanoic acid |
| InChI | InChI=1S/C27H35N11O8/c28-27-36-23-22(25(41)37-27)34-19(16-32-23)15-31-18-3-1-17(2-4-18)24(40)35-20(26(42)43)5-6-21(39)30-7-9-44-11-13-46-14-12-45-10-8-33-38-29/h1-4,16,20,31H,5-15H2,(H,30,39)(H,35,40)(H,42,43)(H3,28,32,36,37,41)/t20-/m0/s1 |
| InChIKey | SWFSDYKTNPMWOV-FQEVSTJZSA-N |
| SMILES | C1=CC(=CC=C1C(=O)NC(CCC(=O)NCCOCCOCCOCCN=[N+]=[N-])C(=O)O)NCC2=CN=C3C(=N2)C(=O)NC(=N3)N |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
