For research use only. Not for therapeutic Use.
Fobrepodacin disodium(CAT: I016864) (also known as ETX0914 or zoliflodacin) is a first-in-class, orally bioavailable spiropyrimidinetrione antibiotic with a novel mechanism of action. It targets bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication, transcription, and repair, but at a site distinct from fluoroquinolones, thereby overcoming common resistance mechanisms. Fobrepodacin disodium has demonstrated potent activity against multidrug-resistant pathogens, including Neisseria gonorrhoeae, making it a promising candidate for treating drug-resistant gonorrhea. With strong oral efficacy, favorable pharmacokinetics, and a novel binding profile, Fobrepodacin disodium represents an important advance in antimicrobial drug development and a valuable research tool for antibacterial resistance studies.
| CAS Number | 1384984-20-6 |
| Synonyms | disodium;2-[5-[2-(ethylcarbamoylamino)-6-fluoro-7-[(2R)-oxolan-2-yl]-3H-benzimidazol-5-yl]pyrimidin-2-yl]propan-2-yl phosphate |
| Molecular Formula | C21H24FN6Na2O6P |
| Purity | ≥95% |
| IUPAC Name | disodium;2-[5-[2-(ethylcarbamoylamino)-6-fluoro-7-[(2R)-oxolan-2-yl]-3H-benzimidazol-5-yl]pyrimidin-2-yl]propan-2-yl phosphate |
| InChI | InChI=1S/C21H26FN6O6P.2Na/c1-4-23-20(29)28-19-26-13-8-12(16(22)15(17(13)27-19)14-6-5-7-33-14)11-9-24-18(25-10-11)21(2,3)34-35(30,31)32;;/h8-10,14H,4-7H2,1-3H3,(H2,30,31,32)(H3,23,26,27,28,29);;/q;2*+1/p-2/t14-;;/m1../s1 |
| InChIKey | BSOLRSNBVIVVMJ-FMOMHUKBSA-L |
| SMILES | CCNC(=O)NC1=NC2=C(N1)C=C(C(=C2C3CCCO3)F)C4=CN=C(N=C4)C(C)(C)OP(=O)([O-])[O-].[Na+].[Na+] |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
