Fmoc-valine

• CAT Number: R023754
• CAS Number: 68858-20-8
• Molecular Formula: C20H21NO4
• Molecular Weight: 339.39
• Purity: ≥95%
• Synonyms: N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-valine;?(2S)-2-[[[(9H-Fluoren-9-yl)methoxy]carbonyl]amino]-3-methylbutanoic Acid; (9-Fluorenylmethoxycarbonyl)valine; (S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-methylbutanoic Acid; (S)-N-Fmoc-valine; 125: PN
• Storage: Store at RT
• IUPAC Name: (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methylbutanoic acid
• InChI: InChI=1S/C20H21NO4/c1-12(2)18(19(22)23)21-20(24)25-11-17-15-9-5-3-7-13(15)14-8-4-6-10-16(14)17/h3-10,12,17-18H,11H2,1-2H3,(H,21,24)(H,22,23)/t18-/m0/s1
• InChIKey: UGNIYGNGCNXHTR-SFHVURJKSA-N
• SMILES: CC(C)C(C(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13

Fmoc-valine(CAT: R023754) is a protected amino acid derivative used primarily in solid-phase peptide synthesis (SPPS). It features the natural amino acid L-valine with its α-amino group protected by the 9-fluorenylmethyloxycarbonyl (Fmoc) group, which can be selectively removed under mild basic conditions. The bulky isopropyl side chain of valine contributes to peptide hydrophobicity and structural rigidity, making it crucial for folding and bioactivity. Fmoc-valine is compatible with standard Fmoc/tBu synthetic protocols and is widely employed in the stepwise construction of peptides and peptidomimetics for pharmaceutical, biochemical, and material science applications. It ensures high purity, reproducibility, and structural integrity in peptide assembly.