Fmoc-Pen(Trt)-OH

• CAT Number: L041963
• CAS Number: 201531-88-6
• Molecular Formula: C39H35NO4S
• Molecular Weight: 613.80
• Purity: ≥95%
• IUPAC Name: (2R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methyl-3-tritylsulfanylbutanoic acid
• InChI: InChI=1S/C39H35NO4S/c1-38(2,45-39(27-16-6-3-7-17-27,28-18-8-4-9-19-28)29-20-10-5-11-21-29)35(36(41)42)40-37(43)44-26-34-32-24-14-12-22-30(32)31-23-13-15-25-33(31)34/h3-25,34-35H,26H2,1-2H3,(H,40,43)(H,41,42)/t35-/m1/s1
• InChIKey: XSGMGAINOILNJR-PGUFJCEWSA-N
• SMILES: CC(C)([C@@H](C(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13)SC(C4=CC=CC=C4)(C5=CC=CC=C5)C6=CC=CC=C6

Fmoc-Pen(Trt)-OH（Cat No.:L041963）is a protected amino acid derivative used in solid-phase peptide synthesis (SPPS). It consists of penicillamine (Pen), a sulfur-containing, β,β-dimethylated cysteine analog, with its thiol group protected by a triphenylmethyl (Trt) group and its α-amino group protected by a fluorenylmethyloxycarbonyl (Fmoc) group. The free carboxylic acid allows coupling to peptide chains. This dual protection strategy preserves functional group integrity during synthesis while enabling selective deprotection. Fmoc-Pen(Trt)-OH is typically a white to off-white solid and is essential in designing peptides requiring sterically hindered or thiol-sensitive residues. Store under dry, inert conditions.