Fmoc-Pen(Acm)-OH

• CAT Number: L046283
• CAS Number: 201531-76-2
• Molecular Formula: C23H26N2O5S
• Molecular Weight: 442.50
• Purity: ≥95%
• IUPAC Name: (2R)-3-(acetamidomethylsulfanyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methylbutanoic acid
• InChI: InChI=1S/C23H26N2O5S/c1-14(26)24-13-31-23(2,3)20(21(27)28)25-22(29)30-12-19-17-10-6-4-8-15(17)16-9-5-7-11-18(16)19/h4-11,19-20H,12-13H2,1-3H3,(H,24,26)(H,25,29)(H,27,28)/t20-/m1/s1
• InChIKey: HJXCJYNKTHOYRD-HXUWFJFHSA-N
• SMILES: CC(=O)NCSC(C)(C)[C@@H](C(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13

Fmoc-Pen(Acm)-OH（Cat No.:L046283）is a protected form of the amino acid penicillamine, used in solid-phase peptide synthesis (SPPS). The Fmoc (9-fluorenylmethyloxycarbonyl) group protects the N-terminus, allowing stepwise chain elongation under mild base conditions, while the Acm (acetamidomethyl) group protects the thiol side chain of penicillamine, preventing premature oxidation or disulfide formation. This derivative is especially useful when synthesizing peptides containing disulfide bridges, as the Acm group can be selectively removed under specific conditions. Fmoc-Pen(Acm)-OH is valued for introducing steric bulk and thiol functionality in synthetic peptides.