Fmoc-PEG6-NHS ester

• CAT Number: I016396
• CAS Number: 1818294-31-3
• Molecular Formula: C34H44N2O12
• Molecular Weight: 672.72
• Purity: ≥95%
• Synonyms: (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate
• InChI: InChI=1S/C34H44N2O12/c37-31-9-10-32(38)36(31)48-33(39)11-13-41-15-17-43-19-21-45-23-24-46-22-20-44-18-16-42-14-12-35-34(40)47-25-30-28-7-3-1-5-26(28)27-6-2-4-8-29(27)30/h1-8,30H,9-25H2,(H,35,40)
• InChIKey: KFJXLDJJJJQTGL-UHFFFAOYSA-N
• SMILES: C1CC(=O)N(C1=O)OC(=O)CCOCCOCCOCCOCCOCCOCCNC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24

Fmoc-PEG6-NHS ester(CAT: I016396) is a bifunctional PEGylated reagent designed for peptide synthesis and bioconjugation. It features an Fmoc-protected amine, a six-unit polyethylene glycol (PEG6) spacer, and an N-hydroxysuccinimide (NHS) ester. The Fmoc group enables compatibility with solid-phase peptide synthesis (SPPS), offering controlled stepwise functionalization. The PEG6 spacer enhances hydrophilicity, flexibility, and solubility while minimizing steric hindrance during coupling reactions. The activated NHS ester reacts efficiently with primary amines to form stable amide bonds. This reagent is widely applied in the preparation of PEGylated peptides, biomolecule conjugates, and linker strategies for drug discovery, diagnostics, and material science research.