Fmoc-PEG2-C2-NHS ester

• CAT Number: I016397
• CAS Number: 1807534-85-5
• Molecular Formula: C26H28N2O8
• Molecular Weight: 496.51
• Purity: ≥95%
• Synonyms: (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethoxy]ethoxy]propanoate
• InChI: InChI=1S/C26H28N2O8/c29-23-9-10-24(30)28(23)36-25(31)11-13-33-15-16-34-14-12-27-26(32)35-17-22-20-7-3-1-5-18(20)19-6-2-4-8-21(19)22/h1-8,22H,9-17H2,(H,27,32)
• InChIKey: MLMVUZTWJNGUEN-UHFFFAOYSA-N
• SMILES: C1CC(=O)N(C1=O)OC(=O)CCOCCOCCNC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24

Fmoc-PEG2-C2-NHS ester(CAT: I016397) is a heterobifunctional PEG linker designed for peptide synthesis and bioconjugation. It features an Fmoc-protected amine, a short PEG2-C2 spacer, and an N-hydroxysuccinimide (NHS) ester. The Fmoc group ensures compatibility with solid-phase peptide synthesis (SPPS), enabling stepwise functionalization and controlled incorporation. The PEG2-C2 spacer provides hydrophilicity, flexibility, and reduced steric hindrance, improving solubility and coupling efficiency. The activated NHS ester reacts readily with primary amines to yield stable amide bonds. This reagent is widely applied in the preparation of PEGylated peptides, biomolecule modifications, and linker strategies in drug discovery, chemical biology, and material science research.