Fmoc-PEG12-NHS ester

• CAT Number: I016650
• CAS Number: 2227246-92-4
• Molecular Formula: C46H68N2O18
• Molecular Weight: 937.03
• Purity: ≥95%
• IUPAC Name: (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate
• InChI: InChI=1S/C46H68N2O18/c49-43-9-10-44(50)48(43)66-45(51)11-13-53-15-17-55-19-21-57-23-25-59-27-29-61-31-33-63-35-36-64-34-32-62-30-28-60-26-24-58-22-20-56-18-16-54-14-12-47-46(52)65-37-42-40-7-3-1-5-38(40)39-6-2-4-8-41(39)42/h1-8,42H,9-37H2,(H,47,52)
• InChIKey: HQKUPHFWWTZASE-UHFFFAOYSA-N
• SMILES: C1CC(=O)N(C1=O)OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24

Fmoc-PEG12-NHS ester(CAT: I016650) is a heterobifunctional polyethylene glycol (PEG) reagent featuring an Fmoc-protected amine and an N-hydroxysuccinimide (NHS) ester, separated by a PEG12 spacer. The NHS ester allows efficient conjugation to primary amines on proteins, peptides, or small molecules, while the Fmoc group serves as a removable protecting group for sequential synthetic modifications. The PEG12 chain enhances solubility, flexibility, and reduces steric hindrance, offering optimal spacing in conjugation strategies. This reagent is widely applied in peptide synthesis, bioconjugation, and drug delivery research, enabling precise PEGylation and linker design in the development of advanced biomedical materials and therapeutic constructs.