Fmoc-Nip-OH

• CAT Number: M041978
• CAS Number: 193693-68-4
• Molecular Formula: C21H21NO4
• Molecular Weight: 351.40
• Purity: ≥95%
• Storage: -20°C
• IUPAC Name: (3S)-1-(9H-fluoren-9-ylmethoxycarbonyl)piperidine-3-carboxylic acid
• InChI: InChI=1S/C21H21NO4/c23-20(24)14-6-5-11-22(12-14)21(25)26-13-19-17-9-3-1-7-15(17)16-8-2-4-10-18(16)19/h1-4,7-10,14,19H,5-6,11-13H2,(H,23,24)/t14-/m0/s1
• InChIKey: FINXGQXNIBNREL-AWEZNQCLSA-N
• SMILES: C1C[C@@H](CN(C1)C(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24)C(=O)O

Fmoc-Nip-OH (Cat No.:M041978) is an Fmoc-protected, non-standard amino acid derivative used in solid-phase peptide synthesis (SPPS). The molecule features an N-isopropyl-substituted glycine backbone, contributing steric bulk and hydrophobicity to peptide chains. The Fmoc group protects the amino functionality during stepwise synthesis and is easily removed under basic conditions, ensuring compatibility with standard SPPS protocols. Fmoc-Nip-OH is valuable for introducing conformational constraints, modulating peptide folding, and enhancing bioactivity or membrane permeability in peptides. It is often employed in designing peptidomimetics and functionalized peptides for biochemical and pharmaceutical research.