Fmoc-NH-PEG8-NHS ester

• CAT Number: I016398
• CAS Number: 1334170-03-4
• Molecular Formula: C38H52N2O14
• Molecular Weight: 760.82
• Purity: ≥95%
• Synonyms: (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[2-[2-[2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate
• InChI: InChI=1S/C38H52N2O14/c41-35-9-10-36(42)40(35)54-37(43)11-13-45-15-17-47-19-21-49-23-25-51-27-28-52-26-24-50-22-20-48-18-16-46-14-12-39-38(44)53-29-34-32-7-3-1-5-30(32)31-6-2-4-8-33(31)34/h1-8,34H,9-29H2,(H,39,44)
• InChIKey: AMSAHSNOOQLQOU-UHFFFAOYSA-N
• SMILES: C1CC(=O)N(C1=O)OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24

Fmoc-NH-PEG8-NHS ester(CAT: I016398) is a bifunctional PEG linker designed for peptide synthesis, bioconjugation, and chemical biology applications. It incorporates an Fmoc-protected amine, an eight-unit polyethylene glycol (PEG8) spacer, and an N-hydroxysuccinimide (NHS) ester. The Fmoc group enables straightforward use in solid-phase peptide synthesis (SPPS) with controlled deprotection, while the NHS ester reacts efficiently with primary amines to form stable amide bonds. The PEG8 spacer enhances water solubility, flexibility, and minimizes steric hindrance, improving reaction efficiency in conjugation. This reagent is widely applied in PEGylated peptide preparation, biomolecule modification, and drug discovery strategies where long, hydrophilic linkers are required.