Fmoc-NH-PEG12-CH2CH2COOH

• CAT Number: I016226
• CAS Number: 1952360-91-6
• Molecular Formula: C42H65NO16
• Molecular Weight: 839.96
• Purity: ≥95%
• Synonyms: 3-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
• InChI: InChI=1S/C42H65NO16/c44-41(45)9-11-47-13-15-49-17-19-51-21-23-53-25-27-55-29-31-57-33-34-58-32-30-56-28-26-54-24-22-52-20-18-50-16-14-48-12-10-43-42(46)59-35-40-38-7-3-1-5-36(38)37-6-2-4-8-39(37)40/h1-8,40H,9-35H2,(H,43,46)(H,44,45)
• InChIKey: JYNHRDJTWNEGJE-UHFFFAOYSA-N
• SMILES: C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)O

Fmoc-NH-PEG12-CH2CH2COOH(CAT: I016226) is a long, monodisperse polyethylene glycol linker functionalized with an Fmoc-protected amine and a terminal carboxylic acid group. The Fmoc protection allows controlled amine deprotection for incorporation into solid-phase peptide synthesis (SPPS) or other amide-coupling workflows, while the carboxyl group provides a versatile reactive handle for conjugation to amines or hydroxyls. The PEG12 spacer imparts high solubility, extended hydrophilicity, and flexibility, minimizing steric hindrance during bioconjugation. This reagent is particularly useful for developing inhibitors, antibody–drug conjugates, and peptide–drug hybrids, where precise spacing and enhanced biocompatibility are required in cancer, metabolic, neurological, and immunological disease research.