Fmoc N-Hydroxysuccinimide Ester

• CAT Number: R013663
• CAS Number: 82911-69-1
• Molecular Formula: C19H15NO5
• Molecular Weight: 337.33
• Purity: ≥95%
• Synonyms: Carbonic Acid 2,5-Dioxo-1-pyrrolidinyl 9H-Fluoren-9-ylmethyl Ester; Fmoc-OSu; 1-[[(9H-Fluoren-9-ylmethoxy)carbonyl]oxy]-2,5-pyrrolidinedione; (Fluorenylmethoxycarbonyl)hydroxysuccinimide Ester; Succinimidyl (9-Fluorenyl)methyl Carbonate; N-(9H-Fluore
• Storage: -20°C
• IUPAC Name: (2,5-dioxopyrrolidin-1-yl) 9H-fluoren-9-ylmethyl carbonate
• InChI: InChI=1S/C19H15NO5/c21-17-9-10-18(22)20(17)25-19(23)24-11-16-14-7-3-1-5-12(14)13-6-2-4-8-15(13)16/h1-8,16H,9-11H2
• InChIKey: WMSUFWLPZLCIHP-UHFFFAOYSA-N
• SMILES: C1CC(=O)N(C1=O)OC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24

Fmoc N-hydroxysuccinimide ester (Cat No.: R013663) is a widely used reagent in peptide synthesis for introducing the fluorenylmethyloxycarbonyl (Fmoc) protecting group onto amino groups. It features an activated N-hydroxysuccinimide (NHS) ester, which reacts efficiently with primary amines to form stable urethane (carbamate) linkages. Fmoc-OSu provides a convenient, mild, and base-labile method for protecting amino functionalities, essential in solid-phase peptide synthesis (SPPS). Its popularity stems from the ease of deprotection and minimal side reactions, ensuring high purity in peptide assembly.