Fmoc-MMAE

• CAT Number: I045032
• CAS Number: 474645-26-6
• Molecular Formula: C54H77N5O9
• Molecular Weight: 940.22
• Purity: ≥95%
• Synonyms: 9H-fluoren-9-ylmethyl N-[(2S)-1-[[(2S)-1-[[(3R,4S,5S)-1-[(2S)-2-[(1R,2R)-3-[[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino]-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-methylamino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-N-methylcarbamate
• InChI: InChI=1S/C54H77N5O9/c1-13-34(6)48(44(66-11)30-45(60)59-29-21-28-43(59)50(67-12)35(7)51(62)55-36(8)49(61)37-22-15-14-16-23-37)57(9)53(64)46(32(2)3)56-52(63)47(33(4)5)58(10)54(65)68-31-42-40-26-19-17-24-38(40)39-25-18-20-27-41(39)42/h14-20,22-27,32-36,42-44,46-50,61H,13,21,28-31H2,1-12H3,(H,55,62)(H,56,63)/t34-,35+,36+,43-,44+,46-,47-,48-,49+,50+/m0/s1
• InChIKey: ZBRLIYBOHHIZKY-NMDVRVFRSA-N
• SMILES: CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@@H]([C@@H](C)C(=O)N[C@H](C)[C@H](C2=CC=CC=C2)O)OC)OC)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)N(C)C(=O)OCC3C4=CC=CC=C4C5=CC=CC=C35

Fmoc-MMAE (Cat No.:I045032) is a functionalized cytotoxic payload used in the synthesis of antibody-drug conjugates (ADCs). MMAE is a potent antimitotic agent that inhibits tubulin polymerization, leading to cell cycle arrest and apoptosis. The Fmoc (9-fluorenylmethyloxycarbonyl) group protects the amino terminus during peptide synthesis, allowing site-specific incorporation into linker-drug systems. Fmoc-MMAE is widely used in ADC development to target cancer cells selectively while minimizing off-target toxicity. Its high potency and compatibility with solid-phase synthesis make it a critical component in next-generation targeted cancer therapies.