Fmoc-L-aspartic Acid β-tert-butyl Ester

• CAT Number: R024370
• CAS Number: 71989-14-5
• Molecular Formula: C23H25NO6
• Molecular Weight: 411.45
• Purity: ≥95%
• Synonyms: (2S)-4-tert-Butoxy-2-[[[(9H-fluoren-9-yl)methoxy]carbonyl]amino]-4-oxobutanoic Acid; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-tert-butoxy-4-oxo-butanoic Acid; 4-tert-Butyl N-(fluoren-9-ylmethoxycarbonyl)-L-aspartate; N-(9-Fluorenylmethoxyc
• Storage: Store at -20°C
• IUPAC Name: (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-[(2-methylpropan-2-yl)oxy]-4-oxobutanoic acid
• InChI: InChI=1S/C23H25NO6/c1-23(2,3)30-20(25)12-19(21(26)27)24-22(28)29-13-18-16-10-6-4-8-14(16)15-9-5-7-11-17(15)18/h4-11,18-19H,12-13H2,1-3H3,(H,24,28)(H,26,27)/t19-/m0/s1
• InChIKey: FODJWPHPWBKDON-IBGZPJMESA-N
• SMILES: CC(C)(C)OC(=O)CC(C(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13

Fmoc-L-aspartic acid β-tert-butyl ester(CAT: R024370) is a protected amino acid derivative widely used in solid-phase peptide synthesis (SPPS). It features an Fmoc (9-fluorenylmethyloxycarbonyl) group protecting the α-amino group and a tert-butyl ester shielding the β-carboxyl side chain, allowing for selective deprotection and sequential peptide elongation. This dual protection ensures compatibility with Fmoc-based SPPS protocols, minimizing side reactions and racemization. The compound is ideal for synthesizing peptides containing aspartic acid residues, particularly when orthogonal deprotection strategies are needed. Its stability, solubility, and ease of handling make it a critical reagent in the production of high-purity custom peptides and peptide-based therapeutics.