For research use only. Not for therapeutic Use.
Fmoc-Gly₃-Val-Cit-PAB（Cat No.:I045869）is a synthetic peptide linker intermediate frequently used in antibody-drug conjugate (ADC) and targeted therapeutic research. It features an N-terminal Fmoc-protected tri-glycine sequence, providing flexibility and synthetic accessibility. The Val-Cit dipeptide is a well-established cathepsin B–cleavable motif, ensuring selective intracellular activation within tumor environments. The para-aminobenzyl (PAB) self-immolative spacer promotes efficient payload release following enzymatic cleavage. This modular design combines stability in circulation with controlled drug liberation, making it a valuable tool for chemical biology, drug development, and precision therapeutic strategies.
| CAS Number | 2647914-09-6 |
| Synonyms | 9H-fluoren-9-ylmethyl N-[2-[[2-[[2-[[(2S)-1-[[(2S)-5-(carbamoylamino)-1-[4-(hydroxymethyl)anilino]-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-2-oxoethyl]amino]-2-oxoethyl]carbamate |
| Molecular Formula | C39H48N8O9 |
| Purity | ≥95% |
| IUPAC Name | 9H-fluoren-9-ylmethyl N-[2-[[2-[[2-[[(2S)-1-[[(2S)-5-(carbamoylamino)-1-[4-(hydroxymethyl)anilino]-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-2-oxoethyl]amino]-2-oxoethyl]carbamate |
| InChI | InChI=1S/C39H48N8O9/c1-23(2)35(37(53)46-31(12-7-17-41-38(40)54)36(52)45-25-15-13-24(21-48)14-16-25)47-34(51)20-43-32(49)18-42-33(50)19-44-39(55)56-22-30-28-10-5-3-8-26(28)27-9-4-6-11-29(27)30/h3-6,8-11,13-16,23,30-31,35,48H,7,12,17-22H2,1-2H3,(H,42,50)(H,43,49)(H,44,55)(H,45,52)(H,46,53)(H,47,51)(H3,40,41,54)/t31-,35-/m0/s1 |
| InChIKey | ANTAWRUQHZQAGZ-ZJJOJAIXSA-N |
| SMILES | CC(C)[C@@H](C(=O)N[C@@H](CCCNC(=O)N)C(=O)NC1=CC=C(C=C1)CO)NC(=O)CNC(=O)CNC(=O)CNC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
