Fmoc-Gly-Gly-Phe-OH

• CAT Number: I045443
• CAS Number: 160036-44-2
• Molecular Formula: C28H27N3O6
• Molecular Weight: 501.53
• Purity: ≥95%
• Synonyms: (2S)-2-[[2-[[2-(9H-fluoren-9-ylmethoxycarbonylamino)acetyl]amino]acetyl]amino]-3-phenylpropanoic acid
• InChI: InChI=1S/C28H27N3O6/c32-25(29-16-26(33)31-24(27(34)35)14-18-8-2-1-3-9-18)15-30-28(36)37-17-23-21-12-6-4-10-19(21)20-11-5-7-13-22(20)23/h1-13,23-24H,14-17H2,(H,29,32)(H,30,36)(H,31,33)(H,34,35)/t24-/m0/s1
• InChIKey: UFGUUZVZUIXKQZ-DEOSSOPVSA-N
• SMILES: C1=CC=C(C=C1)CC(C(=O)O)NC(=O)CNC(=O)CNC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24

Fmoc-Gly-Gly-Phe-OH (Cat No.: I045443) is an N-terminally Fmoc-protected tripeptide consisting of glycine-glycine-phenylalanine, ending with a free carboxylic acid group. The Fmoc (9-fluorenylmethoxycarbonyl) group protects the amino terminus, enabling stepwise solid-phase peptide synthesis (SPPS) using mild base-mediated deprotection. The Gly-Gly segment offers flexibility, while the phenylalanine residue provides hydrophobic and aromatic character, influencing peptide structure and interactions. This building block is widely used in synthetic peptide chemistry, biochemical research, and drug development for constructing bioactive peptides, linkers, and peptide-based conjugates in medicinal and chemical biology studies.

Reference

[1]. Antibody-drug conjugate. Patent WO2014057687A1