Fmoc-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH

• CAT Number: I040495
• CAS Number: 2264011-98-3
• Molecular Formula: C33H35N5O9
• Molecular Weight: 645.66
• Purity: ≥95%
• Synonyms: 2-[[[2-[[(2S)-2-[[2-[[2-(9H-fluoren-9-ylmethoxycarbonylamino)acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]acetyl]amino]methoxy]acetic acid
• InChI: InChI=1S/C33H35N5O9/c39-28(16-36-33(45)47-18-26-24-12-6-4-10-22(24)23-11-5-7-13-25(23)26)34-17-30(41)38-27(14-21-8-2-1-3-9-21)32(44)35-15-29(40)37-20-46-19-31(42)43/h1-13,26-27H,14-20H2,(H,34,39)(H,35,44)(H,36,45)(H,37,40)(H,38,41)(H,42,43)/t27-/m0/s1
• InChIKey: JOZGCSZISBFCOO-MHZLTWQESA-N
• SMILES: C1=CC=C(C=C1)CC(C(=O)NCC(=O)NCOCC(=O)O)NC(=O)CNC(=O)CNC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24

Fmoc-Gly-Gly-Phe-Gly-NH-CH₂-O-CH₂COOH(CAT: I040495) is a functionalized tetrapeptide derivative featuring an Fmoc-protected N-terminus and a modified C-terminal glycolic acid moiety. Composed of glycine-glycine-phenylalanine-glycine, this sequence is commonly used in peptide-drug conjugates and protease-cleavable linker systems. The flexible and hydrophilic spacer (–NH–CH₂–O–CH₂COOH) allows for effective conjugation to drug payloads or carrier molecules, enhancing solubility and controlled release. The phenylalanine residue contributes to hydrophobic interactions and protease recognition. This compound is ideal for research in targeted drug delivery, including antibody-drug conjugates (ADCs), enzyme-responsive systems, and prodrug design. Supplied in high purity for use in synthetic peptide chemistry and biomedical research.