Fmoc-Glu(OtBu)-OH

• CAT Number: L015001
• CAS Number: 71989-18-9
• Molecular Formula: C24H27NO6
• Molecular Weight: 425.50
• Purity: ≥95%
• IUPAC Name: (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-5-[(2-methylpropan-2-yl)oxy]-5-oxopentanoic acid
• InChI: InChI=1S/C24H27NO6/c1-24(2,3)31-21(26)13-12-20(22(27)28)25-23(29)30-14-19-17-10-6-4-8-15(17)16-9-5-7-11-18(16)19/h4-11,19-20H,12-14H2,1-3H3,(H,25,29)(H,27,28)/t20-/m0/s1
• InChIKey: OTKXCALUHMPIGM-FQEVSTJZSA-N
• SMILES: CC(C)(C)OC(=O)CC[C@@H](C(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13

Fmoc-Glu(OtBu)-OH（Cat No.:L015001）is a protected form of the amino acid glutamic acid, commonly used in solid-phase peptide synthesis (SPPS). It features an Fmoc (9-fluorenylmethyloxycarbonyl) group protecting the α-amino group and a tert-butyl (OtBu) ester shielding the γ-carboxyl side chain, leaving the α-carboxyl group free for coupling. This dual protection ensures regioselective peptide bond formation and prevents side reactions during chain elongation. Fmoc-Glu(OtBu)-OH is essential in synthesizing peptides with glutamic acid residues, offering high stability, compatibility with Fmoc-based protocols, and efficient deprotection under mildly basic and acidic conditions.