Fmoc-Glu-OtBu

• CAT Number: L043089
• CAS Number: 84793-07-7
• Molecular Formula: C24H27NO6
• Molecular Weight: 425.51
• Purity: ≥95%
• IUPAC Name: (4S)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-5-[(2-methylpropan-2-yl)oxy]-5-oxopentanoic acid
• InChI: InChI=1S/C24H27NO6/c1-24(2,3)31-22(28)20(12-13-21(26)27)25-23(29)30-14-19-17-10-6-4-8-15(17)16-9-5-7-11-18(16)19/h4-11,19-20H,12-14H2,1-3H3,(H,25,29)(H,26,27)/t20-/m0/s1
• InChIKey: GOPWHXPXSPIIQZ-FQEVSTJZSA-N
• SMILES: CC(C)(C)OC(=O)[C@H](CCC(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13

Fmoc-Glu-OtBu(CAT: L043089) (N-α-Fmoc-L-glutamic acid tert-butyl ester) is a protected amino acid derivative widely used in solid-phase peptide synthesis (SPPS). It features an Fmoc (9-fluorenylmethyloxycarbonyl) group protecting the α-amino group and a tert-butyl ester protecting the side-chain γ-carboxyl group of glutamic acid. This dual protection strategy ensures selective deprotection and coupling during stepwise peptide assembly. Fmoc-Glu-OtBu provides high purity and reliability for constructing peptides and peptidomimetics with acid-sensitive sequences. It is compatible with standard Fmoc/tBu chemistry and widely applied in pharmaceutical development, biochemical research, and custom peptide manufacturing.