FMOC-Arg(Pbf)-OH

• CAT Number: M096975
• CAS Number: 154445-77-9
• Molecular Formula: C34H40N4O7S
• Molecular Weight: 648.77
• Purity: ≥95%
• Storage: Store at RT
• IUPAC Name: (2S)-5-[[amino-[(2,2,4,6,7-pentamethyl-3H-1-benzofuran-5-yl)sulfonylamino]methylidene]amino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)pentanoic acid
• InChI: InChI=1S/C34H40N4O7S/c1-19-20(2)30(21(3)26-17-34(4,5)45-29(19)26)46(42,43)38-32(35)36-16-10-15-28(31(39)40)37-33(41)44-18-27-24-13-8-6-11-22(24)23-12-7-9-14-25(23)27/h6-9,11-14,27-28H,10,15-18H2,1-5H3,(H,37,41)(H,39,40)(H3,35,36,38)/t28-/m0/s1
• InChIKey: HNICLNKVURBTKV-NDEPHWFRSA-N
• SMILES: CC1=C2C(=C(C(=C1C)S(=O)(=O)NC(=NCCCC(C(=O)O)NC(=O)OCC3C4=CC=CC=C4C5=CC=CC=C35)N)C)CC(O2)(C)C

FMOC-Arg(Pbf)-OH(CAT: M096975) is a protected form of the amino acid L-arginine, commonly used in Fmoc solid-phase peptide synthesis (SPPS). The FMOC (9-fluorenylmethyloxycarbonyl) group protects the N-terminal amine, while the Pbf (2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl) group safeguards the arginine side chain guanidino function. This dual-protection ensures selective deprotection and efficient coupling during peptide chain assembly, minimizing side reactions. FMOC-Arg(Pbf)-OH is highly valued for synthesizing arginine-rich peptides, cell-penetrating sequences, and biologically active peptides involved in signaling and enzymatic regulation. It provides excellent stability, solubility, and compatibility with standard SPPS protocols, making it a critical reagent in both research and pharmaceutical peptide production.