Fmoc-3-aminomethyl-phenylacetic acid

• CAT Number: L046326
• CAS Number: 631915-50-9
• Molecular Formula: C24H21NO4
• Molecular Weight: 387.4
• Purity: ≥95%
• IUPAC Name: 2-[3-[(9H-fluoren-9-ylmethoxycarbonylamino)methyl]phenyl]acetic acid
• InChI: InChI=1S/C24H21NO4/c26-23(27)13-16-6-5-7-17(12-16)14-25-24(28)29-15-22-20-10-3-1-8-18(20)19-9-2-4-11-21(19)22/h1-12,22H,13-15H2,(H,25,28)(H,26,27)
• InChIKey: YQDLUJIUWRFNCH-UHFFFAOYSA-N
• SMILES: C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)NCC4=CC=CC(=C4)CC(=O)O

Fmoc-3-aminomethyl-phenylacetic acid(CAT: L046326) is a protected amino acid derivative with the molecular formula C₂₄H₂₁NO₄, featuring a phenylacetic acid core substituted at the 3-position with an aminomethyl group, protected by a fluorenylmethyloxycarbonyl (Fmoc) group. It appears as a white to off-white crystalline solid, sparingly soluble in water but readily soluble in common organic solvents such as DMF, DCM, and methanol. This compound is widely used in solid-phase peptide synthesis (SPPS) to introduce functionalized aromatic residues into peptide chains. The Fmoc group ensures selective protection of the amine, enabling orthogonal deprotection strategies for efficient assembly of complex bioactive peptides and peptidomimetics.