Flurbiprofen

  • CAT Number: A001126
  • CAS Number: 5104-49-4
  • Molecular Formula: C15H13FO2
  • Molecular Weight: 244.3
  • Purity: ≥95%
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Flurbiprofen is a member of the phenylalkanoic acid derivative family of non-steroidal anti-inflammatory drugs (NSAIDs). It is primarily indicated as a pre-operative anti-miotic (in an ophthalmic solution) as well as orally for arthritis or dental pain. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen is structurally and pharmacologically related to fenoprofen, ibuprofen, and ketoprofen.

Catalog Number A001126
CAS Number 5104-49-4
Molecular Formula

C15H13FO2

Purity 95%
Target PGE synthase
Solubility >11.35mg/mL in DMSO
Storage 3 years -20C powder
InChIKey SYTBZMRGLBWNTM-UHFFFAOYSA-N
Reference

</br>1:Enantioselective resolution of racemic flurbiprofen methyl ester by lipase encapsulated mercapto calix[4]arenes capped Fe<sub>3</sub>O<sub>4</sub> nanoparticles. Yildiz H, Ozyilmaz E, Bhatti AA, Yilmaz M.Bioprocess Biosyst Eng. 2017 May 9. doi: 10.1007/s00449-017-1779-x. [Epub ahead of print] PMID: 28488138 </br>2:Core-shell alginate-ghatti gum modified montmorillonite composite matrices for stomach-specific flurbiprofen delivery. Bera H, Ippagunta SR, Kumar S, Vangala P.Mater Sci Eng C Mater Biol Appl. 2017 Jul 1;76:715-726. doi: 10.1016/j.msec.2017.03.074. Epub 2017 Mar 11. PMID: 28482582 </br>3:The efficacy and safety of S-flurbiprofen plaster in the treatment of knee osteoarthritis: a phase II, randomized, double-blind, placebo-controlled, dose-finding study. Yataba I, Otsuka N, Matsushita I, Matsumoto H, Hoshino Y.J Pain Res. 2017 Apr 11;10:867-880. doi: 10.2147/JPR.S131779. eCollection 2017. PMID: 28442928 Free PMC Article</br>4:Flurbiprofen Axetil Provides Effective Analgesia Without Changing the Pregnancy Rate in Ultrasound-Guided Transvaginal Oocyte Retrieval: A Double-Blind Randomized Controlled Trial. Zhao H, Feng Y, Jiang Y, Lu Q.Anesth Analg. 2017 Apr 19. doi: 10.1213/ANE.0000000000002025. [Epub ahead of print] PMID: 28430684 </br>5:Controlled precipitation for enhanced dissolution rate of flurbiprofen: development of rapidly disintegrating tablets. Essa EA, Elmarakby AO, Donia AMA, El Maghraby GM.Drug Dev Ind Pharm. 2017 Apr 24:1-10. doi: 10.1080/03639045.2017.1318905. [Epub ahead of print] PMID: 28402193 </br>6:A pH-independent instantaneous release of flurbiprofen: a study of the preparation of complexes, their characterization and in vitro/in vivo evaluation. Wang HB, Yang FF, Gai XM, Cheng BC, Li JY, Pan H, Yang XG, Pan WS.Drug Dev Ind Pharm. 2017 Apr 24:1-12. doi: 10.1080/03639045.2017.1318908. [Epub ahead of print] PMID: 28402143 </br>7:A minimal impact of long-term S-flurbiprofen plaster application on kidney function in osteoarthritis patients. Otsuka N, Yataba I, Matsushita I, Matsumoto H, Hoshino Y, Terada Y.Clin Exp Nephrol. 2017 Apr 4. doi: 10.1007/s10157-017-1406-9. [Epub ahead of print] PMID: 28378068 </br>8:Extended release of flurbiprofen from tromethamine-buffered HPMC hydrophilic matrix tablets. Pygall S, Kujawinski S, Timmins P, Melia C.Pharm Dev Technol. 2017 Mar 16:1-8. doi: 10.1080/10837450.2017.1301470. [Epub ahead of print] PMID: 28298171 </br>9:Ultrafast Fluorescence Dynamics in Flurbiprofen-Amino Acid Dyads and in the Supramolecular Drug/Protein Complex. Vayá I, Jiménez MC, Miranda MA, Chatterjee A, Gustavsson T.Chimia (Aarau). 2017 Feb 22;71(1):18-25. doi: 10.2533/chimia.2017.18. PMID: 28259191 </br>10:Enantioselective Effect of Flurbiprofen on Lithium Disposition in Rats. Uwai Y, Matsumoto M, Kawasaki T, Nabekura T.Pharmacology. 2017;99(5-6):236-239. doi: 10.1159/000455917. Epub 2017 Feb 2. PMID: 28147361

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