Fluorizoline

• CAT Number: I027606
• CAS Number: 1362243-70-6
• Molecular Formula: C15H8Cl2F3NS
• Molecular Weight: 362.19
• Purity: 98%
• Synonyms: Fluorizoline
• Target: Apoptosis
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 2,5-Bis-(4-chloro-phenyl)-4,4,5-trifluoro-4,5-dihydro-thiazole
• InChI: InChI=1S/C15H8Cl2F3NS/c16-11-5-1-9(2-6-11)13-21-15(19,20)14(18,22-13)10-3-7-12(17)8-4-10/h1-8H
• InChIKey: JGDLZQYCDVDWNE-UHFFFAOYSA-N
• SMILES: FC1(C2=CC=C(Cl)C=C2)C(F)(F)N=C(C3=CC=C(Cl)C=C3)S1

Fluorizoline (Cat.No:I027606) is a first-in-class inducer of p53-independent apoptosis in a wide range of tumor cell lines. It directly binds to prohibitin 1 and 2 (PHBs), two proteins involved in the regulation of several cellular processes, including apoptosis.

Reference

1: Wierz M, Pierson S, Chouha N, Désaubry L, François JH, Berchem G, Paggetti J, Moussay E. The prohibitin-binding compound fluorizoline induces apoptosis in chronic lymphocytic leukemia cells ex vivo but fails to prevent leukemia development in a murine model. Haematologica. 2018 Jan 5. pii: haematol.2017.175349. doi: 10.3324/haematol.2017.175349. [Epub ahead of print] PubMed PMID: 29305413.
2: Cosialls AM, Pomares H, Iglesias-Serret D, Saura-Esteller J, Núñez-Vázquez S, González-Gironès DM, de la Banda E, Preciado S, Albericio F, Lavilla R, Pons G, González-Barca EM, Gil J. The prohibitin-binding compound fluorizoline induces apoptosis in chronic lymphocytic leukemia cells through the upregulation of NOXA and synergizes with ibrutinib, 5-aminoimidazole-4-carboxamide riboside or venetoclax. Haematologica. 2017 Sep;102(9):1587-1593. doi: 10.3324/haematol.2016.162958. Epub 2017 Jun 15. PubMed PMID: 28619845; PubMed Central PMCID: PMC5685241.
3: Yurugi H, Marini F, Weber C, David K, Zhao Q, Binder H, Désaubry L, Rajalingam K. Targeting prohibitins with chemical ligands inhibits KRAS-mediated lung tumours. Oncogene. 2017 Aug 17;36(33):4778-4789. doi: 10.1038/onc.2017.93. Epub 2017 Apr 17. Erratum in: Oncogene. 2017 Aug 28;:. PubMed PMID: 28414306.
4: Pomares H, Palmeri CM, Iglesias-Serret D, Moncunill-Massaguer C, Saura-Esteller J, Núñez-Vázquez S, Gamundi E, Arnan M, Preciado S, Albericio F, Lavilla R, Pons G, González-Barca EM, Cosialls AM, Gil J. Targeting prohibitins induces apoptosis in acute myeloid leukemia cells. Oncotarget. 2016 Oct 4;7(40):64987-65000. doi: 10.18632/oncotarget.11333. PubMed PMID: 27542247; PubMed Central PMCID: PMC5323132.
5: Moncunill-Massaguer C, Saura-Esteller J, Pérez-Perarnau A, Palmeri CM, Núñez-Vázquez S, Cosialls AM, González-Gironès DM, Pomares H, Korwitz A, Preciado S, Albericio F, Lavilla R, Pons G, Langer T, Iglesias-Serret D, Gil J. A novel prohibitin-binding compound induces the mitochondrial apoptotic pathway through NOXA and BIM upregulation. Oncotarget. 2015 Dec 8;6(39):41750-65. doi: 10.18632/oncotarget.6154. PubMed PMID: 26497683; PubMed Central PMCID: PMC4747186.