Fluorescein hydrazide

• CAT Number: I042601
• CAS Number: 78044-20-9
• Molecular Formula: C20H14N2O4
• Molecular Weight: 346.34
• Purity: ≥95%
• Synonyms: 2-(3,6-dihydroxy-9H-xanthen-9-yl)benzohydrazide
• InChI: InChI=1S/C20H16N2O4/c21-22-20(25)14-4-2-1-3-13(14)19-15-7-5-11(23)9-17(15)26-18-10-12(24)6-8-16(18)19/h1-10,19,23-24H,21H2,(H,22,25)
• InChIKey: DHEJDHPRYHYLKS-UHFFFAOYSA-N
• SMILES: C1=CC=C(C(=C1)C2C3=C(C=C(C=C3)O)OC4=C2C=CC(=C4)O)C(=O)NN

Fluorescein hydrazide (Cat No.: I042601) is a fluorescent dye derivative featuring a hydrazide functional group, allowing selective reaction with aldehydes and ketones to form hydrazone bonds. It retains the strong green fluorescence of fluorescein, making it ideal for labeling and detecting carbonyl-containing biomolecules such as sugars, oxidized proteins, and aldehyde-modified nucleotides. Commonly used in bioimaging, diagnostics, and analytical chemistry, fluorescein hydrazide provides high sensitivity and specificity in fluorescence-based assays, supporting research in oxidative stress, glycation, and targeted molecular labeling.

Reference

[1]. Yusha Feng, et al. A novel “turn-on” thiooxofluorescein-based colorimetric and fluorescent sensor for Hg2+ and its application in living cells. Talanta. 2017 Aug 1;170:103-110.
[Content Brief]

[2]. Xie Zhihui, et al. Sensitive colorimetric and fluorescent detection of mercury using fluorescein derivatives. Open Journal of Applied Biosensor.Volume: 1.Issue: 3.Pages: 44-52, 9 pp. Journal. 2012.