Fluocinolone (Acetonide)

• CAT Number: A000234
• CAS Number: 67-73-2
• Molecular Formula: C24H30F2O6
• Molecular Weight: 452.49
• Purity: ≥95%
• Synonyms: (1S,2S,4R,8S,9S,11S,12R,13S,19S)-12,19-difluoro-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one
• InChI: InChI=1S/C24H30F2O6/c1-20(2)31-19-9-13-14-8-16(25)15-7-12(28)5-6-21(15,3)23(14,26)17(29)10-22(13,4)24(19,32-20)18(30)11-27/h5-7,13-14,16-17,19,27,29H,8-11H2,1-4H3/t13-,14-,16-,17-,19+,21-,22-,23-,24+/m0/s1
• InChIKey: FEBLZLNTKCEFIT-VSXGLTOVSA-N
• SMILES: C[C@]12C[C@@H]([C@]3([C@H]([C@@H]1C[C@@H]4[C@]2(OC(O4)(C)C)C(=O)CO)C[C@@H](C5=CC(=O)C=C[C@@]53C)F)F)O

Fluocinolone acetonide（Cat No.:A000234）is a synthetic corticosteroid with potent anti-inflammatory, antipruritic, and vasoconstrictive properties, used primarily in dermatology. With the molecular formula C24H30F2O6, it is a fluorinated derivative of hydrocortisone, formulated for topical use to treat skin conditions such as eczema, psoriasis, and allergic dermatitis. It works by suppressing the release of inflammatory mediators and reducing swelling, redness, and itching. Fluocinolone acetonide is available in creams, ointments, and scalp solutions, and is also used in intravitreal implants for treating diabetic macular edema. Long-term use may cause skin thinning or other corticosteroid-related side effects.

Reference

[1]. Nguyen L T H, et al. The potential of fluocinolone acetonide to mitigate inflammation and lipid accumulation in 2D and 3D foam cell cultures [J]. BioMed Research International, 2018, 2018.

[2]. Liu Z, et al. Fluocinolone acetonide promotes the proliferation and mineralization of dental pulp cells [J]. Journal of endodontics, 2013, 39(2): 217-222.

[3]. Cetinkaya-Fisgin A, et al. Identification of fluocinolone acetonide to prevent paclitaxel‐induced peripheral neuropathy [J]. Journal of the Peripheral Nervous System, 2016, 21(3): 128-133.

[4]. Nehmé A, et al. Glucocorticoids with different chemical structures but similar glucocorticoid receptor potency regulate subsets of common and unique genes in human trabecular meshwork cells [J]. BMC medical genomics, 2009, 2(1): 1-14.

[5]. http://en.wikipedia.org/wiki/Fluocinolone_acetonide

[6]. Nehme, A., et al., Glucocorticoids with different chemical structures but similar glucocorticoid receptor potency regulate subsets of common and unique genes in human trabecular meshwork cells. BMC Med Genomics, 2009. 2: p. 58.
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