Flumazenil

• CAT Number: A000422
• CAS Number: 78755-81-4
• Molecular Formula: C15H14FN3O3
• Molecular Weight: 303.30
• Purity: ≥95%
• Synonyms: 78755-81-4; Anexate; Flumazepil; Romazicon; Lanexat
• Target: Neuronal Signaling
• Solubility: Limited solubility
• Storage: -20°C
• IUPAC Name: ethyl 8-fluoro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate
• InChI: InChI=1S/C15H14FN3O3/c1-3-22-15(21)13-12-7-18(2)14(20)10-6-9(16)4-5-11(10)19(12)8-17-13/h4-6,8H,3,7H2,1-2H3
• InChIKey: OFBIFZUFASYYRE-UHFFFAOYSA-N
• SMILES: CCOC(=O)C1=C2CN(C(=O)C3=C(N2C=N1)C=CC(=C3)F)C

Flumazenil (Cat No.: A000422) is a benzodiazepine antagonist used to reverse the sedative effects of benzodiazepines during anesthesia or in cases of overdose. It works by competitively inhibiting benzodiazepine binding at the GABA-A receptor, rapidly restoring consciousness and respiratory function. Administered intravenously, flumazenil acts within minutes but has a short duration, often requiring repeated dosing. Side effects may include nausea, dizziness, agitation, or seizures, particularly in patients with long-term benzodiazepine use or mixed drug overdoses. It is used with caution in such cases.

Overview of Clinical Research

Flumazenil is a GABA-A receptor antagonist used as antidote for benzodiazepine overdoses. Coeruleus has patents pending for flumazenil in world including Japan in 2020.

Reference

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