For research use only. Not for therapeutic Use.
FLT3-IN-4（Cat No.:I018997）is a potent and selective small-molecule inhibitor of FMS-like tyrosine kinase 3 (FLT3), a receptor tyrosine kinase frequently mutated or overexpressed in acute myeloid leukemia (AML). By blocking FLT3 signaling, it suppresses downstream pathways that drive cell proliferation and survival. FLT3-IN-4 is widely applied in oncology research to investigate leukemogenesis, drug resistance, and targeted therapeutic strategies. Its activity makes it a valuable preclinical tool for studying tyrosine kinase inhibition and cancer biology, supporting the development of novel treatments for AML and related hematologic malignancies.
| CAS Number | 2304799-09-3 |
| Synonyms | 1-[4-(4-amino-7-prop-2-enylpyrrolo[2,3-d]pyrimidin-5-yl)phenyl]-3-(5-tert-butyl-1,2-oxazol-3-yl)urea |
| Molecular Formula | C23H25N7O2 |
| Purity | ≥95% |
| IUPAC Name | 1-[4-(4-amino-7-prop-2-enylpyrrolo[2,3-d]pyrimidin-5-yl)phenyl]-3-(5-tert-butyl-1,2-oxazol-3-yl)urea |
| InChI | InChI=1S/C23H25N7O2/c1-5-10-30-12-16(19-20(24)25-13-26-21(19)30)14-6-8-15(9-7-14)27-22(31)28-18-11-17(32-29-18)23(2,3)4/h5-9,11-13H,1,10H2,2-4H3,(H2,24,25,26)(H2,27,28,29,31) |
| InChIKey | XIMGYPHSYIMHAW-UHFFFAOYSA-N |
| SMILES | CC(C)(C)C1=CC(=NO1)NC(=O)NC2=CC=C(C=C2)C3=CN(C4=NC=NC(=C34)N)CC=C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
