• CAT Number: I027527
  • CAS Number: 495-98-7
  • Molecular Formula: C12H20N2O
  • Molecular Weight: 208.305
  • Purity: 98%
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Flavacol(CAT: I027527) is a food-grade additive used primarily in the popcorn industry to enhance the flavor and appearance of popcorn. It is a yellowish powder composed of various ingredients, including salt, artificial butter flavor, and yellow food coloring. Flavacol is typically sprinkled onto freshly popped popcorn to provide a distinctive buttery taste and a bright, yellow color.

Catalog Number I027527
CAS Number 495-98-7
Molecular Formula


Purity 98
Solubility Soluble in DMSO
Storage Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
IUPAC Name 3,6-diisobutylpyrazin-2(1H)-one
InChI InChI=1S/C12H20N2O/c1-8(2)5-10-7-13-11(6-9(3)4)12(15)14-10/h7-9H,5-6H2,1-4H3,(H,14,15)

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Sent On: Tue Aug 04 16:49:39 2020
Search: flavanol Filters: Review
20 selected items
PubMed Results
Items 1-20 of 20 (Display the 20 citations in PubMed)
1: Decroix L, Soares DD, Meeusen R, Heyman E, Tonoli C. Cocoa Flavanol Supplementation and Exercise: A Systematic Review. Sports Med. 2018 Apr;48(4):867-892. doi: 10.1007/s40279-017-0849-1. PMID: 29299877.
2: Lin X, Zhang I, Li A, Manson JE, Sesso HD, Wang L, Liu S. Cocoa Flavanol Intake and Biomarkers for Cardiometabolic Health: A Systematic Review and Meta- Analysis of Randomized Controlled Trials. J Nutr. 2016 Nov;146(11):2325-2333. doi: 10.3945/jn.116.237644. Epub 2016 Sep 28. PMID: 27683874; PMCID: PMC5086796.
3: Jumar A, Schmieder RE. Cocoa Flavanol Cardiovascular Effects Beyond Blood Pressure Reduction. J Clin Hypertens (Greenwich). 2016 Apr;18(4):352-8. doi: 10.1111/jch.12715. Epub 2015 Oct 30. PMID: 26514936.
4: Nehlig A. The neuroprotective effects of cocoa flavanol and its influence on cognitive performance. Br J Clin Pharmacol. 2013 Mar;75(3):716-27. doi: 10.1111/j.1365-2125.2012.04378.x. PMID: 22775434; PMCID: PMC3575938.
5: Garcia JP, Santana A, Baruqui DL, Suraci N. The Cardiovascular effects of chocolate. Rev Cardiovasc Med. 2018 Dec 30;19(4):123-127. doi: 10.31083/j.rcm.2018.04.3187. PMID: 31064163.
6: Ried K, Fakler P, Stocks NP. Effect of cocoa on blood pressure. Cochrane Database Syst Rev. 2017 Apr 25;4(4):CD008893. doi: 10.1002/14651858.CD008893.pub3. PMID: 28439881; PMCID: PMC6478304.
7: Tuenter E, Foubert K, Pieters L. Mood Components in Cocoa and Chocolate: The Mood Pyramid. Planta Med. 2018 Aug;84(12-13):839-844. doi: 10.1055/a-0588-5534. Epub 2018 Mar 14. PMID: 29539647.
8: Williamson G. The role of polyphenols in modern nutrition. Nutr Bull. 2017 Sep;42(3):226-235. doi: 10.1111/nbu.12278. Epub 2017 Aug 15. PMID: 28983192; PMCID: PMC5601283.
9: Magrone T, Russo MA, Jirillo E. Cocoa and Dark Chocolate Polyphenols: From Biology to Clinical Applications. Front Immunol. 2017 Jun 9;8:677. doi: 10.3389/fimmu.2017.00677. PMID: 28649251; PMCID: PMC5465250.
10: Mehrinfar R, Frishman WH. Flavanol-rich cocoa: a cardioprotective nutraceutical. Cardiol Rev. 2008 May-Jun;16(3):109-15. doi: 10.1097/CRD.0b013e31815d95e2. PMID: 18414181.
11: Socci V, Tempesta D, Desideri G, De Gennaro L, Ferrara M. Enhancing Human Cognition with Cocoa Flavonoids. Front Nutr. 2017 May 16;4:19. doi: 10.3389/fnut.2017.00019. PMID: 28560212; PMCID: PMC5432604.
12: Scholey A, Owen L. Effects of chocolate on cognitive function and mood: a systematic review. Nutr Rev. 2013 Oct;71(10):665-81. doi: 10.1111/nure.12065. PMID: 24117885.
13: Durazzo A, Lucarini M, Souto EB, Cicala C, Caiazzo E, Izzo AA, Novellino E, Santini A. Polyphenols: A concise overview on the chemistry, occurrence, and human health. Phytother Res. 2019 Sep;33(9):2221-2243. doi: 10.1002/ptr.6419. Epub 2019 Jul 29. PMID: 31359516.
14: Bernatoniene J, Kopustinskiene DM. The Role of Catechins in Cellular Responses to Oxidative Stress. Molecules. 2018 Apr 20;23(4):965. doi: 10.3390/molecules23040965. PMID: 29677167; PMCID: PMC6017297.
15: Sokolov AN, Pavlova MA, Klosterhalfen S, Enck P. Chocolate and the brain: neurobiological impact of cocoa flavanols on cognition and behavior. Neurosci Biobehav Rev. 2013 Dec;37(10 Pt 2):2445-53. doi: 10.1016/j.neubiorev.2013.06.013. Epub 2013 Jun 26. PMID: 23810791.
16: Jurikova T, Mlcek J, Skrovankova S, Sumczynski D, Sochor J, Hlavacova I, Snopek L, Orsavova J. Fruits of Black Chokeberry Aronia melanocarpa in the Prevention of Chronic Diseases. Molecules. 2017 Jun 7;22(6):944. doi: 10.3390/molecules22060944. PMID: 28590446; PMCID: PMC6152740.
17: Dhakad AK, Ikram M, Sharma S, Khan S, Pandey VV, Singh A. Biological, nutritional, and therapeutic significance of Moringa oleifera Lam. Phytother Res. 2019 Nov;33(11):2870-2903. doi: 10.1002/ptr.6475. Epub 2019 Aug 27. PMID: 31453658.
18: Sies H, Hollman PC, Grune T, Stahl W, Biesalski HK, Williamson G. Protection by flavanol-rich foods against vascular dysfunction and oxidative damage: 27th Hohenheim Consensus Conference. Adv Nutr. 2012 Mar 1;3(2):217-21. doi: 10.3945/an.111.001578. PMID: 22516731; PMCID: PMC3648724.
19: Jaramillo Flores ME. Cocoa Flavanols: Natural Agents with Attenuating Effects on Metabolic Syndrome Risk Factors. Nutrients. 2019 Mar 30;11(4):751. doi: 10.3390/nu11040751. PMID: 30935075; PMCID: PMC6520706.
20: Perez-Vizcaino F, Fraga CG. Research trends in flavonoids and health. Arch Biochem Biophys. 2018 May 15;646:107-112. doi: 10.1016/j.abb.2018.03.022. Epub 2018 Mar 23. PMID: 29580946.

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