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CAS No.: 1637735-84-2
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| Product Details | |
|---|---|
For research use only. Not Intended for Therapeutic Use! |
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| Cat No: | I002130 |
| Synonyms: | N-(4-((3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)ureido)methyl)phenyl)acrylamide |
| Molecular Formula: | C34H36Cl2N8O4 |
| Molecular Weight: | 691.6 |
| Description: | FIIN-3 is an irreversible inhibitor of FGFR1-4 with IC50s of 13, 21, 31, and 35 nM, respectively. FIIN-3strongly inhibited EGFR, with an IC50 of 204 nM. (1) FIIN-3 can potently inhibit the proliferation of cells (2) FIIN-3 can inhibit the proliferation of Ba/F3 cells engineer to be dependent on FGFR and EGFR kinase activity. |
| Price: | Get quote |
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FIIN-3 is an irreversible inhibitor of FGFR1-4 with IC50s of 13, 21, 31, and 35 nM, respectively. FIIN-3strongly inhibited EGFR, with an IC50 of 204 nM.
(1) FIIN-3 can potently inhibit the proliferation of cells
(2) FIIN-3 can inhibit the proliferation of Ba/F3 cells engineer to be dependent on FGFR and EGFR kinase activity.
(3)FIIN-3 is more potent than FIIN-2 and BGJ398 in inhibiting the AKT and ERK1/2 phosphorylation and proliferation of SKOV-3 cells.
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