FIIN-3- CAS 1637735-84-2

CAS No.: 1637735-84-2

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FIIN-3,1637735-84-2
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I002130
Synonyms:

N-(4-((3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)ureido)methyl)phenyl)acrylamide

Molecular Formula:

C34H36Cl2N8O4

Molecular Weight:691.6
Description: FIIN-3 is an irreversible inhibitor of FGFR1-4 with IC50s of 13, 21, 31, and 35 nM, respectively. FIIN-3strongly inhibited EGFR, with an IC50 of 204 nM. (1) FIIN-3 can potently inhibit the proliferation of cells (2) FIIN-3 can inhibit the proliferation of Ba/F3 cells engineer to be dependent on FGFR and EGFR kinase activity.
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FIIN-3 is an irreversible inhibitor of FGFR1-4 with IC50s of 13, 21, 31, and 35 nM, respectively. FIIN-3strongly inhibited EGFR, with an IC50 of 204 nM.



(1) FIIN-3 can potently inhibit the proliferation of cells

(2) FIIN-3 can inhibit the proliferation of Ba/F3 cells engineer to be dependent on FGFR and EGFR kinase activity.

(3)FIIN-3 is more potent than FIIN-2 and BGJ398 in inhibiting the AKT and ERK1/2 phosphorylation and proliferation of SKOV-3 cells.

Chem Calculators

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