For research use only. Not for therapeutic Use.
FIIN-1（Cat No.:R059763）is an irreversible small-molecule inhibitor of fibroblast growth factor receptors (FGFRs), a family of receptor tyrosine kinases involved in cell proliferation, differentiation, angiogenesis, and oncogenesis. By covalently binding to FGFR, FIIN-1 effectively suppresses aberrant FGFR signaling pathways that drive tumor growth and survival. It has been particularly valuable in preclinical studies of FGFR-dependent cancers, including bladder and lung cancers. As a chemical probe, FIIN-1 enables the study of FGFR biology, resistance mechanisms to kinase inhibitors, and the development of novel targeted therapies in oncology research.
| CAS Number | 1256152-35-8 |
| Synonyms | N-[3-[[3-(2,6-dichloro-3,5-dimethoxyphenyl)-7-[4-(diethylamino)butylamino]-2-oxo-4H-pyrimido[4,5-d]pyrimidin-1-yl]methyl]phenyl]prop-2-enamide |
| Molecular Formula | C32H39Cl2N7O4 |
| Purity | ≥95% |
| IUPAC Name | N-[3-[[3-(2,6-dichloro-3,5-dimethoxyphenyl)-7-[4-(diethylamino)butylamino]-2-oxo-4H-pyrimido[4,5-d]pyrimidin-1-yl]methyl]phenyl]prop-2-enamide |
| InChI | InChI=1S/C32H39Cl2N7O4/c1-6-26(42)37-23-13-11-12-21(16-23)19-41-30-22(18-36-31(38-30)35-14-9-10-15-39(7-2)8-3)20-40(32(41)43)29-27(33)24(44-4)17-25(45-5)28(29)34/h6,11-13,16-18H,1,7-10,14-15,19-20H2,2-5H3,(H,37,42)(H,35,36,38) |
| InChIKey | DNVFTXQYIYFQBW-UHFFFAOYSA-N |
| SMILES | CCN(CC)CCCCNC1=NC=C2CN(C(=O)N(C2=N1)CC3=CC(=CC=C3)NC(=O)C=C)C4=C(C(=CC(=C4Cl)OC)OC)Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
