Fidaxomicin - CAS 873857-62-6
Fidaxomicin(CAS 873857-62-6), a macrocyclic antibiotic, has a narrow spectrum of activity against gram-positive anaerobes and is bactericidal against C. difficile.
Fidaxomicin inhibits bacterial transcription by binding to RNA polymerase, a large enzyme that consists of five subunits that comprise its core catalytic enzyme (α2 ββ/' ω) and a separate sigma (σ) subunit responsible for promoter recognition. Fidaxomicin has no activity against gram-negative bacteria. Fidaxomicin has minimal activity against Bacteroides species, which may be advantageous in maintaining colonization resistance and protecting the gastrointestinal tract from colonization by C. difficile.
Catalog Number: A000989
CAS Number: 873857-62-6
PubChem Substance ID:348273081
Molecular Formula: C52H74Cl2O18
Molecular Weight:1058.04
Purity: ≥95%
Inventory:In Stock
* For research use only. Not for human or veterinary use.
Synonym
Synonyms | OPT-80, PAR-101 |
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Property
Molecular Formula: | C52H74Cl2O18 |
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Molecular Weight | 1058.04 |
Target: | RNA polymerase |
Purity | ≥95% |
Storage | -20°C |
Overview of Clinical Research | Fidaxomicin is a protein synthesis inhibitor developed by Abott Laboratories. There is no orphan drug yet. |
Computed Descriptor
IUPAC Name | [(2R,3S,4S,5S,6R)-6-[[(3E,5E,8S,9E,11S,12R,13E,15E,18S)-12-[(2R,3S,4R,5S)-3,4-dihydroxy-6,6-dimethyl-5-(2-methylpropanoyloxy)oxan-2-yl]oxy-11-ethyl-8-hydroxy-18-[(1R)-1-hydroxyethyl]-9,13,15-trimethyl-2-oxo-1-oxacyclooctadeca-3,5,9,13,15-pentaen-3-yl]methoxy]-4-hydroxy-5-methoxy-2-methyloxan-3-yl] 3,5-dichloro-2-ethyl-4,6-dihydroxybenzoate |
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InChI | InChI=1S/C52H74Cl2O18/c1-13-30-22-26(6)33(56)18-16-15-17-31(23-66-51-45(65-12)42(61)44(29(9)67-51)69-49(64)35-32(14-2)36(53)39(58)37(54)38(35)57)48(63)68-34(28(8)55)20-19-25(5)21-27(7)43(30)70-50-41(60)40(59)46(52(10,11)72-50)71-47(62)24(3)4/h15-17,19,21- |
InChIKey | ZVGNESXIJDCBKN-LGPUCNCQSA-N |
SMILES | CCC1C=C(C(CC=CC=C(C(=O)OC(CC=C(C=C(C1OC2C(C(C(C(O2)(C)C)OC(=O)C(C)C)O)O)C)C)C(C)O)COC3C(C(C(C(O3)C)OC(=O)C4=C(C(=C(C(=C4O)Cl)O)Cl)CC)O)OC)O)C |