Fidaxomicin - CAS 873857-62-6


Fidaxomicin(CAS 873857-62-6), a macrocyclic antibiotic, has a narrow spectrum of activity against gram-positive anaerobes and is bactericidal against C. difficile. 



Fidaxomicin inhibits bacterial transcription by binding to RNA polymerase, a large enzyme that consists of five subunits that comprise its core catalytic enzyme (α2 ββ/' ω) and a separate sigma (σ) subunit responsible for promoter recognition. Fidaxomicin has no activity against gram-negative bacteria. Fidaxomicin has minimal activity against Bacteroides species, which may be advantageous in maintaining colonization resistance and protecting the gastrointestinal tract from colonization by C. difficile. 

Catalog Number: A000989

CAS Number: 873857-62-6

PubChem Substance ID:348273081

Molecular Formula: C52H74Cl2O18

Molecular Weight:1058.04

Purity: ≥95%

Inventory:In Stock

* For research use only. Not for human or veterinary use.

Synonym

SynonymsOPT-80, PAR-101

Property

Molecular Formula: C52H74Cl2O18
Molecular Weight1058.04
Target:RNA polymerase
Purity≥95%
Storage-20°C
Overview of Clinical ResearchFidaxomicin is a protein synthesis inhibitor developed by Abott Laboratories. There is no orphan drug yet.

Computed Descriptor

IUPAC Name[(2R,3S,4S,5S,6R)-6-[[(3E,5E,8S,9E,11S,12R,13E,15E,18S)-12-[(2R,3S,4R,5S)-3,4-dihydroxy-6,6-dimethyl-5-(2-methylpropanoyloxy)oxan-2-yl]oxy-11-ethyl-8-hydroxy-18-[(1R)-1-hydroxyethyl]-9,13,15-trimethyl-2-oxo-1-oxacyclooctadeca-3,5,9,13,15-pentaen-3-yl]methoxy]-4-hydroxy-5-methoxy-2-methyloxan-3-yl] 3,5-dichloro-2-ethyl-4,6-dihydroxybenzoate
InChIInChI=1S/C52H74Cl2O18/c1-13-30-22-26(6)33(56)18-16-15-17-31(23-66-51-45(65-12)42(61)44(29(9)67-51)69-49(64)35-32(14-2)36(53)39(58)37(54)38(35)57)48(63)68-34(28(8)55)20-19-25(5)21-27(7)43(30)70-50-41(60)40(59)46(52(10,11)72-50)71-47(62)24(3)4/h15-17,19,21-
InChIKeyZVGNESXIJDCBKN-LGPUCNCQSA-N
SMILESCCC1C=C(C(CC=CC=C(C(=O)OC(CC=C(C=C(C1OC2C(C(C(C(O2)(C)C)OC(=O)C(C)C)O)O)C)C)C(C)O)COC3C(C(C(C(O3)C)OC(=O)C4=C(C(=C(C(=C4O)Cl)O)Cl)CC)O)OC)O)C