FHD-286

• CAT Number: I044040
• CAS Number: 2671128-05-3
• Molecular Formula: C24H30N6O6S2
• Molecular Weight: 562.66
• Purity: ≥95%
• Synonyms: N-[(2S)-1-[[4-[6-[(2R,6S)-2,6-dimethylmorpholin-4-yl]pyridin-2-yl]-1,3-thiazol-2-yl]amino]-3-methoxy-1-oxopropan-2-yl]-1-methylsulfonylpyrrole-3-carboxamide
• IUPAC Name: N-[(2S)-1-[[4-[6-[(2S,6R)-2,6-dimethylmorpholin-4-yl]pyridin-2-yl]-1,3-thiazol-2-yl]amino]-3-methoxy-1-oxopropan-2-yl]-1-methylsulfonylpyrrole-3-carboxamide
• InChI: InChI=1S/C24H30N6O6S2/c1-15-10-29(11-16(2)36-15)21-7-5-6-18(25-21)20-14-37-24(27-20)28-23(32)19(13-35-3)26-22(31)17-8-9-30(12-17)38(4,33)34/h5-9,12,14-16,19H,10-11,13H2,1-4H3,(H,26,31)(H,27,28,32)/t15-,16+,19-/m0/s1
• InChIKey: JBLQNFBXKOAIHG-FCEWJHQRSA-N
• SMILES: C[C@@H]1CN(C[C@@H](O1)C)C2=CC=CC(=N2)C3=CSC(=N3)NC(=O)[C@H](COC)NC(=O)C4=CN(C=C4)S(=O)(=O)C

FHD-286（Cat No.:I044040）is a selective and potent allosteric inhibitor of BRG1 (SMARCA4) and BRM (SMARCA2), the catalytic subunits of the SWI/SNF chromatin remodeling complex. By targeting these ATPases, FHD-286 disrupts chromatin accessibility and transcriptional programs critical for tumor growth and survival, particularly in cancers with SWI/SNF complex dependencies or epigenetic dysregulation. It is especially valuable in research on synovial sarcoma, renal medullary carcinoma, and other SWI/SNF-mutant malignancies. FHD-286 offers a novel approach to studying chromatin remodeling and supports therapeutic strategies aimed at epigenetic vulnerabilities in aggressive and treatment-resistant cancers.