For research use only. Not for therapeutic Use.
FGTI-2734 mesylate(CAT: I046015) is a RAS C-terminal mimetic and dual inhibitor of farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT), with IC50 values of 250 nM and 520 nM, respectively. By disrupting protein prenylation, it prevents KRAS membrane localization, addressing resistance mechanisms in mutant KRAS-driven cancers. FGTI-2734 selectively induces apoptosis in mutant KRAS-dependent human cancer cells (1–30 μM, 72 h) and inhibits prenylation of HDJ2, RAP1A, KRAS, and NRAS. In vivo, intraperitoneal administration (100 mg/kg/day) suppresses tumor growth in mutant KRAS-dependent but not KRAS-independent tumors, making it a valuable tool for KRAS-targeted oncology research.
| CAS Number | 2702297-24-1 |
| Synonyms | N-[2-[4-cyano-2-fluoro-N-[(3-methylimidazol-4-yl)methyl]anilino]ethyl]-N-(cyclohexylmethyl)pyridine-2-sulfonamide;methanesulfonic acid |
| Molecular Formula | C27H35FN6O5S2 |
| Purity | ≥95% |
| IUPAC Name | N-[2-[4-cyano-2-fluoro-N-[(3-methylimidazol-4-yl)methyl]anilino]ethyl]-N-(cyclohexylmethyl)pyridine-2-sulfonamide;methanesulfonic acid |
| InChI | InChI=1S/C26H31FN6O2S.CH4O3S/c1-31-20-29-17-23(31)19-32(25-11-10-22(16-28)15-24(25)27)13-14-33(18-21-7-3-2-4-8-21)36(34,35)26-9-5-6-12-30-26;1-5(2,3)4/h5-6,9-12,15,17,20-21H,2-4,7-8,13-14,18-19H2,1H3;1H3,(H,2,3,4) |
| InChIKey | CVSSKDKRVCBPOV-UHFFFAOYSA-N |
| SMILES | CN1C=NC=C1CN(CCN(CC2CCCCC2)S(=O)(=O)C3=CC=CC=N3)C4=C(C=C(C=C4)C#N)F.CS(=O)(=O)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
