FGF22-IN-1

• CAT Number: I042475
• CAS Number: 113143-13-8
• Molecular Formula: C14H11N3OS
• Molecular Weight: 269.32
• Purity: ≥95%
• Synonyms: N-[(E)-1H-indol-3-ylmethylideneamino]thiophene-2-carboxamide
• InChI: InChI=1S/C14H11N3OS/c18-14(13-6-3-7-19-13)17-16-9-10-8-15-12-5-2-1-4-11(10)12/h1-9,15H,(H,17,18)/b16-9+
• InChIKey: FMKAYIUNMIHSEK-CXUHLZMHSA-N
• SMILES: C1=CC=C2C(=C1)C(=CN2)C=NNC(=O)C3=CC=CS3

FGF22-IN-1 (Cat No.: I042475) is a selective small-molecule inhibitor targeting Fibroblast Growth Factor 22 (FGF22), a member of the FGF family involved in synapse formation, neuronal development, and skin homeostasis. By blocking FGF22 activity, FGF22-IN-1 is used to study its role in central nervous system signaling and peripheral tissue regeneration. This inhibitor aids in dissecting FGF22-specific pathways in both physiological and pathological conditions, including neurodevelopmental disorders, wound healing, and cancer. FGF22-IN-1 is a valuable tool for research in developmental biology and regenerative medicine.

Reference

[1]. Xiao H, et al. Potent inhibition of the CD4-dependent T cell response by J2, a novel nonpeptide organic ligand of CD4 D1. Mol Immunol. 2007 Feb;44(5):784-95.
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