For research use only. Not for therapeutic Use.
Feniralstat（Cat No.:I045108）is an investigational oral plasma kallikrein inhibitor developed for the treatment of hereditary angioedema (HAE), a rare genetic disorder characterized by recurrent swelling attacks. By selectively inhibiting plasma kallikrein, Feniralstat reduces bradykinin production, the key mediator of vascular permeability and edema in HAE. Its oral formulation offers a convenient alternative to injectable therapies, with potential for both prophylactic and on-demand use. Feniralstat aims to provide effective, well-tolerated symptom control and improved quality of life. Supplied for research into bradykinin-mediated diseases and kallikrein-targeted therapeutic strategies.
| CAS Number | 2166320-76-7 |
| Synonyms | N-[(3-fluoro-4-methoxypyridin-2-yl)methyl]-1-[[4-[(5-fluoro-2-oxopyridin-1-yl)methyl]phenyl]methyl]-3-(methoxymethyl)pyrazole-4-carboxamide |
| Molecular Formula | C26H25F2N5O4 |
| Purity | ≥95% |
| IUPAC Name | N-[(3-fluoro-4-methoxypyridin-2-yl)methyl]-1-[[4-[(5-fluoro-2-oxopyridin-1-yl)methyl]phenyl]methyl]-3-(methoxymethyl)pyrazole-4-carboxamide |
| InChI | InChI=1S/C26H25F2N5O4/c1-36-16-22-20(26(35)30-11-21-25(28)23(37-2)9-10-29-21)15-33(31-22)13-18-5-3-17(4-6-18)12-32-14-19(27)7-8-24(32)34/h3-10,14-15H,11-13,16H2,1-2H3,(H,30,35) |
| InChIKey | ZRUFVDPYHLTYPD-UHFFFAOYSA-N |
| SMILES | COCC1=NN(C=C1C(=O)NCC2=NC=CC(=C2F)OC)CC3=CC=C(C=C3)CN4C=C(C=CC4=O)F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
