FEN1-IN-2

• CAT Number: I045516
• CAS Number: 824983-94-0
• Molecular Formula: C20H15N3O4S
• Molecular Weight: 393.42
• Purity: ≥95%
• Synonyms: 4-[3-[(3-hydroxy-2,4-dioxothieno[3,2-d]pyrimidin-1-yl)methyl]phenyl]benzamide
• InChI: InChI=1S/C20H15N3O4S/c21-18(24)14-6-4-13(5-7-14)15-3-1-2-12(10-15)11-22-16-8-9-28-17(16)19(25)23(27)20(22)26/h1-10,27H,11H2,(H2,21,24)
• InChIKey: VQEJSOSSYFEKGH-UHFFFAOYSA-N
• SMILES: C1=CC(=CC(=C1)C2=CC=C(C=C2)C(=O)N)CN3C4=C(C(=O)N(C3=O)O)SC=C4

FEN1-IN-2 (Cat No.: I045516) is a selective small-molecule inhibitor of flap endonuclease 1 (FEN1), a key enzyme in DNA replication and repair. By blocking FEN1 activity, FEN1-IN-2 disrupts Okazaki fragment processing and base excision repair, leading to replication stress and DNA damage accumulation. Researchers use this compound to study DNA repair pathways, replication fidelity, and synthetic lethality in cancer models. Its ability to sensitize tumor cells to DNA-damaging agents makes it a valuable tool for oncology research and therapeutic strategy development.

Reference

[1]. L Nathan Tumey, et al. The identification and optimization of a N-hydroxy urea series of flap endonuclease 1 inhibitors. Bioorg Med Chem Lett. 2005 Jan 17;15(2):277-81.
[Content Brief]