For research use only. Not for therapeutic Use.
FEN1-IN-1（Cat No.:I017875）is a selective small-molecule inhibitor of flap endonuclease 1 (FEN1), a structure-specific nuclease essential for DNA replication, repair, and Okazaki fragment processing. By blocking FEN1 activity, FEN1-IN-1 disrupts DNA repair pathways, leading to replication stress and apoptosis, particularly in cancer cells reliant on enhanced DNA repair capacity. This compound is a valuable tool for investigating genome stability, DNA damage response, and synthetic lethality in oncology research. FEN1-IN-1 supports the exploration of targeted therapeutic strategies aimed at exploiting DNA repair vulnerabilities in tumors.
| CAS Number | 824983-91-7 |
| Synonyms | 1-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-3-hydroxythieno[3,2-d]pyrimidine-2,4-dione |
| Molecular Formula | C15H12N2O5S |
| Purity | ≥95% |
| IUPAC Name | 1-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-3-hydroxythieno[3,2-d]pyrimidine-2,4-dione |
| InChI | InChI=1S/C15H12N2O5S/c18-14-13-10(5-6-23-13)16(15(19)17(14)20)7-9-8-21-11-3-1-2-4-12(11)22-9/h1-6,9,20H,7-8H2 |
| InChIKey | MXQGCMQXTPTJJT-UHFFFAOYSA-N |
| SMILES | C1C(OC2=CC=CC=C2O1)CN3C4=C(C(=O)N(C3=O)O)SC=C4 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
