Febrifugine dihydrochloride

• CAT Number: R040096
• CAS Number: 32434-42-7
• Molecular Formula: C16H21Cl2N3O3
• Molecular Weight: 374.26
• Purity: ≥95%
• Synonyms: 3-[3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl]quinazolin-4-one;dihydrochloride
• InChI: InChI=1S/C16H19N3O3.2ClH/c20-11(8-14-15(21)6-3-7-17-14)9-19-10-18-13-5-2-1-4-12(13)16(19)22;;/h1-2,4-5,10,14-15,17,21H,3,6-9H2;2*1H/t14-,15+;;/m1../s1
• InChIKey: RDUHYEILHQUTIR-AMTWEWDESA-N
• SMILES: C1C[C@@H]([C@H](NC1)CC(=O)CN2C=NC3=CC=CC=C3C2=O)O.Cl.Cl

Febrifugine dihydrochloride（Cat No.:R040096）is a synthetic salt form of febrifugine, the bioactive alkaloid originally isolated from Dichroa febrifuga (Chinese hydrangea). It is best known for its potent antimalarial activity, attributed to inhibition of prolyl-tRNA synthetase, thereby disrupting protein synthesis in Plasmodium species. Beyond its antimalarial effects, febrifugine and derivatives exhibit anti-fibrotic, anti-inflammatory, and anticancer potential, making the compound a versatile research tool. The dihydrochloride form enhances solubility and stability, supporting its use in pharmacological studies, drug development, and biochemical investigations of novel therapeutic targets.