For research use only. Not for therapeutic Use.
FB23（Cat No.:I027299）is a selective small-molecule inhibitor of fat mass and obesity-associated protein (FTO), an m6A RNA demethylase involved in epigenetic regulation of gene expression. By blocking FTO activity, FB23 increases N6-methyladenosine (m6A) levels on RNA, thereby influencing mRNA stability, splicing, and translation. It has shown promise in preclinical models of acute myeloid leukemia (AML), where FTO overexpression contributes to leukemogenesis. FB23 effectively reduces leukemia cell proliferation and promotes differentiation and apoptosis. As an epitranscriptomic modulator, FB23 represents a novel therapeutic approach for targeting RNA modifications in cancer and metabolic diseases.
| CAS Number | 2243736-35-6 |
| Synonyms | 2-[2,6-dichloro-4-(3,5-dimethyl-1,2-oxazol-4-yl)anilino]benzoic acid |
| Molecular Formula | C18H14Cl2N2O3 |
| Purity | ≥95% |
| IUPAC Name | 2-[2,6-dichloro-4-(3,5-dimethyl-1,2-oxazol-4-yl)anilino]benzoic acid |
| InChI | InChI=1S/C18H14Cl2N2O3/c1-9-16(10(2)25-22-9)11-7-13(19)17(14(20)8-11)21-15-6-4-3-5-12(15)18(23)24/h3-8,21H,1-2H3,(H,23,24) |
| InChIKey | VUXZATVQMFSUCM-UHFFFAOYSA-N |
| SMILES | CC1=C(C(=NO1)C)C2=CC(=C(C(=C2)Cl)NC3=CC=CC=C3C(=O)O)Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
