FAPI-46

• CAT Number: I044675
• CAS Number: 2374782-04-2
• Molecular Formula: C41H57F2N11O9
• Molecular Weight: 885.96
• Purity: ≥95%
• Synonyms: 2-[4,7-bis(carboxymethyl)-10-[2-[4-[3-[[4-[[2-[(2S)-2-cyano-4,4-difluoropyrrolidin-1-yl]-2-oxoethyl]carbamoyl]quinolin-6-yl]-methylamino]propyl]piperazin-1-yl]-2-oxoethyl]-1,4,7,10-tetrazacyclododec-1-yl]acetic acid
• InChI: InChI=1S/C41H57F2N11O9/c1-47(30-3-4-34-33(21-30)32(5-6-45-34)40(63)46-24-35(55)54-29-41(42,43)22-31(54)23-44)7-2-8-48-17-19-53(20-18-48)36(56)25-49-9-11-50(26-37(57)58)13-15-52(28-39(61)62)16-14-51(12-10-49)27-38(59)60/h3-6,21,31H,2,7-20,22,24-29H2,1H3,(H,46,63)(H,57,58)(H,59,60)(H,61,62)/t31-/m0/s1
• InChIKey: SDBGUEFOSXNKBX-HKBQPEDESA-N
• SMILES: CN(CCCN1CCN(CC1)C(=O)CN2CCN(CCN(CCN(CC2)CC(=O)O)CC(=O)O)CC(=O)O)C3=CC4=C(C=CN=C4C=C3)C(=O)NCC(=O)N5CC(C[C@H]5C#N)(F)F

FAPI-46 (Cat No.:I044675) is a radiolabeled small molecule that selectively targets fibroblast activation protein (FAP), which is overexpressed in cancer-associated fibroblasts (CAFs) within the tumor microenvironment. Used primarily in diagnostic imaging and theranostics, FAPI-46 enables precise PET imaging of various solid tumors, including pancreatic, breast, and lung cancers. Its rapid tumor uptake, low background signal, and favorable pharmacokinetics make it an effective agent for tumor detection and potential radionuclide therapy. FAPI-46 is a promising tool for cancer diagnosis, staging, and treatment planning in precision oncology.