F 13714 fumarate

• CAT Number: I045496
• CAS Number: 208109-39-1
• Molecular Formula: C25H29ClF2N4O5
• Molecular Weight: 538.97
• Purity: ≥95%
• Synonyms: (E)-but-2-enedioic acid;(3-chloro-4-fluorophenyl)-[4-fluoro-4-[[[5-methyl-6-(methylamino)pyridin-2-yl]methylamino]methyl]piperidin-1-yl]methanone
• InChI: InChI=1S/C21H25ClF2N4O.C4H4O4/c1-14-3-5-16(27-19(14)25-2)12-26-13-21(24)7-9-28(10-8-21)20(29)15-4-6-18(23)17(22)11-15;5-3(6)1-2-4(7)8/h3-6,11,26H,7-10,12-13H2,1-2H3,(H,25,27);1-2H,(H,5,6)(H,7,8)/b;2-1+
• InChIKey: HZJWIYFEDQNBEU-WLHGVMLRSA-N
• SMILES: CC1=C(N=C(C=C1)CNCC2(CCN(CC2)C(=O)C3=CC(=C(C=C3)F)Cl)F)NC.C(=CC(=O)O)C(=O)O

F 13714 fumarate (Cat No.: I045496) is a highly selective serotonin 5-HT₁A receptor agonist with preferential activation of postsynaptic 5-HT₁A receptors over presynaptic autoreceptors. This pharmacological profile enables it to modulate serotonergic neurotransmission while minimizing feedback inhibition, offering potential advantages in treating depression, anxiety, and other mood disorders. The fumarate salt form improves stability and solubility for research or therapeutic use. F 13714 fumarate is investigated in neuropharmacology to explore serotonin receptor signaling, antidepressant mechanisms, and the development of next-generation serotonergic modulators with improved efficacy.

Reference

[1]. Monika Głuch-Lutwin, et al. The selective 5-HT 1A receptor biased agonists, F15599 and F13714, show antidepressant-like properties after a single administration in the mouse model of unpredictable chronic mild stress. Psychopharmacology (Berl). 2021 May 10.
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