For research use only. Not for therapeutic Use.
EZM0414（Cat No.:I044038）is a potent, selective, and orally bioavailable inhibitor of enhancer of zeste homolog 1 and 2 (EZH1/2), the catalytic subunits of the polycomb repressive complex 2 (PRC2). By inhibiting EZH1/2, EZM0414 reduces trimethylation of histone H3 on lysine 27 (H3K27me3), thereby reactivating silenced tumor suppressor genes and altering epigenetic landscapes. It is particularly valuable in hematologic malignancies such as multiple myeloma and diffuse large B-cell lymphoma (DLBCL). EZM0414 is a promising tool for exploring epigenetic dysregulation in cancer and developing targeted therapies aimed at chromatin-modifying enzymes.
| CAS Number | 2411748-50-8 |
| Synonyms | N-[(1R,3S)-3-(4-acetylpiperazin-1-yl)cyclohexyl]-7-fluoro-4-methyl-1H-indole-2-carboxamide |
| Molecular Formula | C22H29FN4O2 |
| Purity | ≥95% |
| IUPAC Name | N-[(1R,3S)-3-(4-acetylpiperazin-1-yl)cyclohexyl]-4-fluoro-7-methyl-1H-indole-2-carboxamide |
| InChI | InChI=1S/C22H29FN4O2/c1-14-6-7-19(23)18-13-20(25-21(14)18)22(29)24-16-4-3-5-17(12-16)27-10-8-26(9-11-27)15(2)28/h6-7,13,16-17,25H,3-5,8-12H2,1-2H3,(H,24,29)/t16-,17+/m1/s1 |
| InChIKey | PGNLXEBQMQHFNK-SJORKVTESA-N |
| SMILES | CC1=C2C(=C(C=C1)F)C=C(N2)C(=O)N[C@@H]3CCC[C@@H](C3)N4CCN(CC4)C(=O)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
