Ezetimibe hydroxy glucuronide

• CAT Number: R008140
• CAS Number: 536709-33-8
• Molecular Formula: C30H29F2NO9
• Molecular Weight: 585.55
• Purity: ≥95%
• Synonyms: (2S,3S,4S,5R,6R)-6-[(1S)-1-(4-fluorophenyl)-3-[(2S,3R)-1-(4-fluorophenyl)-2-(4-hydroxyphenyl)-4-oxoazetidin-3-yl]propoxy]-3,4,5-trihydroxyoxane-2-carboxylic acid
• InChI: InChI=1S/C30H29F2NO9/c31-17-5-1-15(2-6-17)22(41-30-26(37)24(35)25(36)27(42-30)29(39)40)14-13-21-23(16-3-11-20(34)12-4-16)33(28(21)38)19-9-7-18(32)8-10-19/h1-12,21-27,30,34-37H,13-14H2,(H,39,40)/t21-,22+,23-,24+,25+,26-,27+,30-/m1/s1
• InChIKey: MPXLJVWGRVISEQ-ADEYADIWSA-N
• SMILES: C1=CC(=CC=C1C2C(C(=O)N2C3=CC=C(C=C3)F)CCC(C4=CC=C(C=C4)F)OC5C(C(C(C(O5)C(=O)O)O)O)O)O

Ezetimibe Hydroxy Glucuronide(CAT: R008140) is the active metabolite of ezetimibe, a cholesterol absorption inhibitor used to treat hyperlipidemia. Formed through glucuronidation of ezetimibe in the liver and intestinal wall, this metabolite retains potent activity by selectively inhibiting the Niemann-Pick C1-Like 1 (NPC1L1) transporter in the small intestine. This action blocks dietary and biliary cholesterol uptake without affecting the absorption of triglycerides or fat-soluble vitamins. Ezetimibe hydroxy glucuronide is primarily responsible for the therapeutic effects of ezetimibe, circulating systemically and contributing to its long half-life. It is a key molecule in cardiovascular and lipid metabolism research.