(E/Z)-4-Hydroxy Tamoxifen

• CAT Number: R048075
• CAS Number: 68392-35-8
• Molecular Formula: C26H29NO2
• Molecular Weight: 387.51
• Purity: ≥95%
• Synonyms: 4-[1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-phenyl-1-butenyl]phenol; (E/Z)-4-Hydroxytamoxifen; 4-Hydroxytamoxifen; 4-Hydroxy-(E/Z)-tamoxifen; Afimoxifene; TamoGel
• Target: Metabolic Enzyme/Protease
• Solubility: Soluble in DMSO
• Storage: Store at -20°C
• IUPAC Name: 4-[(Z)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol
• InChI: InChI=1S/C26H29NO2/c1-4-25(20-8-6-5-7-9-20)26(21-10-14-23(28)15-11-21)22-12-16-24(17-13-22)29-19-18-27(2)3/h5-17,28H,4,18-19H2,1-3H3/b26-25+
• InChIKey: TXUZVZSFRXZGTL-QPLCGJKRSA-N
• SMILES: CC/C(C1=CC=CC=C1)=C(C2=CC=C(O)C=C2)/C3=CC=C(OCCN(C)C)C=C3

(E/Z)-4-Hydroxy Tamoxifen(CAT: R048075) is a highly potent metabolite of tamoxifen, widely used in cancer research and genetic engineering. Present as a mixture of E and Z isomers, the Z-isomer exhibits significantly higher affinity for estrogen receptors, functioning as a selective estrogen receptor modulator (SERM). It plays a crucial role in the study of estrogen receptor-positive (ER⁺) breast cancer by antagonizing estrogen activity in tumor cells. Additionally, (E/Z)-4-Hydroxy Tamoxifen is commonly utilized in Cre-ERT/loxP recombination systems to enable inducible gene activation or deletion in transgenic models.