Exatecan Intermediate 7

• CAT Number: I040667
• CAS Number: 182182-32-7
• Molecular Formula: C13H13FN2O3
• Molecular Weight: 264.25
• Purity: ≥95%
• Synonyms: N-[(7E)-3-fluoro-7-hydroxyimino-4-methyl-8-oxo-5,6-dihydronaphthalen-1-yl]acetamide
• InChI: InChI=1S/C13H13FN2O3/c1-6-8-3-4-10(16-19)13(18)12(8)11(5-9(6)14)15-7(2)17/h5,19H,3-4H2,1-2H3,(H,15,17)/b16-10+
• InChIKey: TUUIIOPQMWHACM-MHWRWJLKSA-N
• SMILES: CC1=C(C=C(C2=C1CCC(=NO)C2=O)NC(=O)C)F

Exatecan Intermediate 7(CAT: I040667) is a critical compound in the multistep synthesis of Exatecan, a potent topoisomerase I inhibitor used as a cytotoxic payload in antibody-drug conjugates (ADCs). Structurally tailored to support the formation of the active camptothecin core, this intermediate ensures the fidelity and efficiency of downstream synthetic processes. It plays a key role in building the pharmacophore responsible for DNA cleavage and cytotoxicity in rapidly dividing cancer cells. Exatecan Intermediate 7 is highly valued in oncology research and pharmaceutical manufacturing for its role in producing Exatecan-based ADCs such as DS-8201 (trastuzumab deruxtecan), enabling targeted cancer therapy development.