Exatecan Intermediate 5

• CAT Number: I040669
• CAS Number: 143655-70-3
• Molecular Formula: C15H17FN2O3
• Molecular Weight: 292.31
• Purity: ≥95%
• Synonyms: N-(8-acetamido-6-fluoro-5-methyl-1-oxo-3,4-dihydro-2H-naphthalen-2-yl)acetamide
• InChI: InChI=1S/C15H17FN2O3/c1-7-10-4-5-12(17-8(2)19)15(21)14(10)13(6-11(7)16)18-9(3)20/h6,12H,4-5H2,1-3H3,(H,17,19)(H,18,20)
• InChIKey: UNQLSBJKEGXCGH-UHFFFAOYSA-N
• SMILES: CC1=C(C=C(C2=C1CCC(C2=O)NC(=O)C)NC(=O)C)F

Exatecan Intermediate 5(CAT: I040669) is an essential synthetic precursor in the production of Exatecan, a potent camptothecin derivative used as a cytotoxic payload in antibody-drug conjugates (ADCs). This intermediate contributes to the construction of Exatecan’s pentacyclic core, which is critical for its topoisomerase I inhibitory activity. Precisely engineered for high reactivity and structural fidelity, Exatecan Intermediate 5 ensures efficient progression through the multi-step synthesis route, enabling scalable production of Exatecan and its derivatives. It is widely used in oncology research and pharmaceutical development to support the creation of targeted therapies for solid tumors, particularly in ADC platforms like DS-8201.