For research use only. Not for therapeutic Use.
Exatecan analog 36(CAT: I040260) is a structural analog of Exatecan (DX-8951, HY-13631), a potent DNA topoisomerase I inhibitor (IC₅₀ = 2.2 μM) widely used as a cytotoxic payload in antibody-drug conjugates (ADCs). Designed for enhanced synthetic flexibility or tailored pharmacokinetic profiles, this analog serves as a valuable intermediate for developing novel ADC payloads and evaluating structure–activity relationships. Exatecan analog 36 supports research in targeted drug delivery, DNA-damaging chemotherapeutics, and cytotoxic mechanism elucidation. It is ideal for scientists developing next-generation ADCs or exploring topoisomerase I inhibitors for cancer therapy.
| Synonyms | N-(14-fluoro-15-methyl-5-oxo-7-propanoyl-4,11-diazapentacyclo[10.7.1.02,10.04,9.016,20]icosa-1,6,8,10,12,14,16(20)-heptaen-19-yl)acetamide |
| Molecular Formula | C24H22FN3O3 |
| Purity | ≥95% |
| IUPAC Name | N-(14-fluoro-15-methyl-5-oxo-7-propanoyl-4,11-diazapentacyclo[10.7.1.02,10.04,9.016,20]icosa-1,6,8,10,12,14,16(20)-heptaen-19-yl)acetamide |
| InChI | InChI=1S/C24H22FN3O3/c1-4-20(30)13-7-19-24-15(10-28(19)21(31)8-13)23-17(26-12(3)29)6-5-14-11(2)16(25)9-18(27-24)22(14)23/h7-9,17H,4-6,10H2,1-3H3,(H,26,29) |
| InChIKey | UWSSMMLNRVDDTK-UHFFFAOYSA-N |
| SMILES | CCC(=O)C1=CC(=O)N2CC3=C4C(CCC5=C4C(=CC(=C5C)F)N=C3C2=C1)NC(=O)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
