For research use only. Not for therapeutic Use.
EW-7195（Cat No.:I015025）is a small-molecule inhibitor targeting transforming growth factor-beta type I receptor kinase (TGF-βRI/ALK5). By blocking TGF-β signaling, it prevents phosphorylation of Smad2/3 and downstream profibrotic gene expression. EW-7195 has demonstrated strong anti-fibrotic activity in preclinical models, showing efficacy in liver, lung, and kidney fibrosis by suppressing extracellular matrix deposition and epithelial-to-mesenchymal transition (EMT). Beyond fibrosis, it is being explored for cancer research, as TGF-β signaling contributes to tumor progression, metastasis, and immune evasion. EW-7195 provides a promising tool for studying fibrosis and oncology.
| CAS Number | 1352609-28-9 |
| Synonyms | 3-[[5-(6-methylpyridin-2-yl)-4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-imidazol-2-yl]methylamino]benzonitrile |
| Molecular Formula | C23H18N8 |
| Purity | ≥95% |
| IUPAC Name | 3-[[5-(6-methylpyridin-2-yl)-4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-imidazol-2-yl]methylamino]benzonitrile |
| InChI | InChI=1S/C23H18N8/c1-15-4-2-7-19(28-15)23-22(17-8-9-21-26-14-27-31(21)13-17)29-20(30-23)12-25-18-6-3-5-16(10-18)11-24/h2-10,13-14,25H,12H2,1H3,(H,29,30) |
| InChIKey | KEADGKSQIBFYEE-UHFFFAOYSA-N |
| SMILES | CC1=NC(=CC=C1)C2=C(N=C(N2)CNC3=CC=CC(=C3)C#N)C4=CN5C(=NC=N5)C=C4 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
