For research use only. Not for therapeutic Use.
Evifacotrep (Cat No.: I027164) is an oral prodrug of allopregnanolone, a neurosteroid known for its role in modulating GABA-A receptors and promoting neurogenesis, myelination, and neural repair. Developed using deuterated lipid conjugate technology, evifacotrep enhances the bioavailability of allopregnanolone, enabling effective oral delivery. It is being investigated for treating neurological and neuropsychiatric conditions, including depression and neurodegenerative diseases. Evifacotrep aims to provide the therapeutic benefits of allopregnanolone with improved dosing convenience and clinical applicability.
| CAS Number | 2413739-88-3 |
| Synonyms | 5-chloro-4-[4-[4-fluoro-2-(trifluoromethyl)phenoxy]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-7-yl]-1H-pyridazin-6-one |
| Molecular Formula | C18H12ClF4N5O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C18H12ClF4N5O2/c19-15-13(6-26-27-16(15)29)28-4-3-10-12(7-28)24-8-25-17(10)30-14-2-1-9(20)5-11(14)18(21,22)23/h1-2,5-6,8H,3-4,7H2,(H,27,29) |
| InChIKey | IQFZADSTVFSHDX-UHFFFAOYSA-N |
| SMILES | C1CN(CC2=C1C(=NC=N2)OC3=C(C=C(C=C3)F)C(F)(F)F)C4=C(C(=O)NN=C4)Cl |
| Reference | [1]. WO2020061162 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
